Dr Claudio Raimondi
Lecturer
The William Harvey Research Institute
Queen Mary University of London
Queen Mary University of London
Research
Endothelial Cells, Vascular Biology, Shear Stress, Cell Junctions, Cell Signalling, Vascular Inflammation
Interests
My lab focuses on investigating on signalling pathways modulated by shear stress that regulates vascular inflammation. We use an Ibidi 2D shear stress system and we are interested in expanding our focus on more complex 3D organ on chips.Publications
2025
ATP-binding cassette B8 prevents endothelial dysfunction and atherosclerosis.Chaker AB, Rinaldi L, Gillham O, Perez-Ternero C, Bosseboeuf E, Dyson N, Smith DS, Ardehali H et al.
Redox Biology, Elsevier
01-10-2025
2024
Endothelial Neuropilin-1: a multifaced signal transducer with an emerging role in inflammation and atherosclerosis beyond angiogenesisChikh A, Raimondi C
Biochemical Society Transactions, Portland Press vol. 52 (1), 137-150.
07-02-2024
2023
Corrigendum to “Natural mutations of human XDH promote the nitrite (NO2 −)-reductase capacity of xanthine oxidoreductase: A novel mechanism to promote redox health?” [Redox Biol. 4 (67) (2023) 102864]Massimo G, Khambata RS, Chapman T, Birchall K, Raimondi C, Shabbir A, Dyson N, Rathod K et al.
Redox Biology, Elsevier vol. 67
21-10-2023
Natural mutations of human XDH promote the nitrite (NO2 −)-reductase capacity of xanthine oxidoreductase: A novel mechanism to promote redox health?Massimo G, Khambata RS, Chapman T, Birchall K, Raimondi C, Shabbir A, Dyson N, Rathod KS et al.
Redox Biology, Elsevier vol. 67
04-09-2023
Neuropilin-1 interacts with VE-cadherin and TGFBR2 to stabilize adherens junctions and prevent activation of endothelium under flowBosseboeuf E, Chikh A, Chaker AB, Mitchell TP, Vignaraja D, Rajendrakumar R, Khambata RS, Nightingale TD et al.
Science Signaling, American Association For The Advancement of Science (Aaas) vol. 16 (786)
23-05-2023
2022
Retraction: iASPP is a novel autophagy inhibitor in keratinocytesChikh A, Sanzà P, Raimondi C, Akinduro O, Warnes G, Chiorino G, Byrne C, Harwood CA et al.
Journal of Cell Science, The Company of Biologists vol. 135 (14)
15-07-2022
2020
Author Correction: Dynamic regulation of canonical TGFβ signalling by endothelial transcription factor ERG protects from liver fibrogenesis (Nature Communications, (2017), 8, 1, (895), 10.1038/s41467-017-01169-0)Dufton NP, Peghaire CR, Osuna-Almagro L, Raimondi C, Kalna V, Chauhan A, Webb G, Yang Y et al.
Nature Communications vol. 11 (1)
12-11-2020
Signalling, Metabolic Pathways and Iron Homeostasis in Endothelial Cells in Health, Atherosclerosis and Alzheimer’s DiseaseBosseboeuf E, Raimondi C
Cells, Mdpi vol. 9 (9)
08-09-2020
2019
The transcription factor ERG regulates a low shear stress-induced anti-thrombotic pathway in the microvasculaturePeghaire C, Dufton NP, Lang M, Salles-Crawley II, Ahnström J, Kalna V, Raimondi C, Pericleous C et al.
Nature Communications, Springer Nature vol. 10 (1)
01-11-2019
2018
Neuropilin-1 Controls Endothelial Homeostasis by Regulating Mitochondrial Function and Iron-Dependent Oxidative StressIssitt T, Bosseboeuf E, De Winter N, Dufton N, Gestri G, Senatore V, Chikh A, Randi AM et al.
Iscience, Elsevier vol. 11, 205-223.
11-12-2018
2017
Dynamic regulation of canonical TGFβ signalling by endothelial transcription factor ERG protects from liver fibrogenesisDufton NP, Peghaire CR, Osuna-Almagro L, Raimondi C, Kalna V, Chauhan A, Webb G, Yang Y et al.
Nature Communications, Springer Nature vol. 8 (1)
12-10-2017
VEGF165-induced vascular permeability requires NRP1 for ABL-mediated SRC family kinase activationFantin A, Lampropoulou A, Senatore V, Brash JT, Prahst C, Lange CA, Liyanage SE, Raimondi C et al.
Journal of Experimental Medicine, Rockefeller University Press vol. 214 (4), 1049-1064.
13-03-2017
Correction: A novel regulatory mechanism links PLCγ1 to PDK1Raimondi C, Chikh A, Wheeler AP, Maffucci T, Falasca M
Journal of Cell Science, The Company of Biologists vol. 130 (5), 1016-1016.
01-03-2017
2016
A Small Molecule Inhibitor of PDK1/PLCγ1 Interaction Blocks Breast and Melanoma Cancer Cell InvasionRaimondi C, Calleja V, Ferro R, Fantin A, Riley AM, Potter BVL, Brennan CH, Maffucci T et al.
Scientific Reports, Nature Publishing Group: Open Access Journals - Option C vol. 6, 26142-26142.
20-05-2016
2014
Imatinib inhibits VEGF-independent angiogenesis by targeting neuropilin 1-dependent ABL1 activation in endothelial cells.Raimondi C, Fantin A, Lampropoulou A, Denti L, Chikh A, Ruhrberg C
J Exp Med vol. 211 (6), 1167-1183.
02-06-2014
IASPP is a novel autophagy mudulator in keratinocytesChikh A, Sanza P, Raimondi C, Akinduro O, Warnes G, Chiorino G, Byrne C, Harwood CA et al.
J Cell Science, Company of Biologists vol. 127 (14), 3079-3093.
28-04-2014
Phospholipase C beta4 regulates invasion and proliferation in cutaneous SCC in vivoRuban EL, Balogun MA, Martins V, Caley M, Raimondi C, O'toole E, Falasca M
01-01-2014
2013
Phospholipase C-beta 4 regulates proliferation and invasion in cutaneous SCCRuban EL, Martins VL, Caley M, Raimondi C, Falasca M, O'Toole EA
01-01-2013
2012
A novel regulatory mechanism links PLCγ1 to PDK1.Raimondi C, Chikh A, Wheeler AP, Maffucci T, Falasca M
J Cell Sci vol. 125 (Pt 13), 3153-3163.
01-07-2012
Phosphoinositides signalling in cancer: focus on PI3K and PLC.Raimondi C, Falasca M
Adv Biol Regul vol. 52 (1), 166-182.
01-01-2012
2011
iASPP/p63 autoregulatory feedback loop is required for the homeostasis of stratified epithelia.Chikh A, Matin RNH, Senatore V, Hufbauer M, Lavery D, Raimondi C, Ostano P, Mello-Grand M et al.
Embo J vol. 30 (20), 4261-4273.
06-09-2011
Class II phosphoinositide 3-kinase regulates exocytosis of insulin granules in pancreatic beta cells.Dominguez V, Raimondi C, Somanath S, Bugliani M, Loder MK, Edling CE, Divecha N, da Silva-Xavier G et al.
J Biol Chem vol. 286 (6), 4216-4225.
11-02-2011
Targeting PDK1 in cancer.Raimondi C, Falasca M
Curr Med Chem vol. 18 (18), 2763-2769.
01-01-2011
Boyden chamber.Falasca M, Raimondi C, Maffucci T
Methods Mol Biol vol. 769, 87-95.
01-01-2011
2010
A novel and selective PDK1 inhibitor reduces breast cancer cell invasion and tumour growthRaimondi C, Maffucci T, Potter BVI, Falasca M
01-01-2010
2009
A phosphoinositide 3-kinase/phospholipase Cgamma1 pathway regulates fibroblast growth factor-induced capillary tube formation.Maffucci T, Raimondi C, Abu-Hayyeh S, Dominguez V, Sala G, Zachary I, Falasca M
Plos One vol. 4 (12)
14-12-2009
2008
Phospholipase Cgamma1 is required for metastasis development and progression.Sala G, Dituri F, Raimondi C, Previdi S, Maffucci T, Mazzoletti M, Rossi C, Iezzi M et al.
Cancer Res vol. 68 (24), 10187-10196.
15-12-2008
1992
Prognostic significance of thallium-201 scintigraphy in patients with previous myocardial infarct.Astorri E, Ferrari O, Lima G, Garini A, Arisi M, Manzetti G, Raimondi C
Minerva Cardioangiologica vol. 40 (1-2), 7-13.
01-01-1992
Grants
Role of microvascular dysfunction in MELAS: impact of a mtDNA mutation on microvascular functionClaudio Raimondi
£27,000 BHF British Heart Foundation
01-03-2023 - 28-02-2026
Neuropilin-1 is a novel iron-induced gene that protects vascular functionClaudio Raimondi
£43,361 Barts and the London Charity
15-09-2023 - 01-02-2025
ABCB8 is a novel regulator of endothelial function and homeostasisClaudio Raimondi
£221,021 Barts and the London Charity
25-10-2021 - 23-01-2025
Role of neuropilin-1 in controlling endothelial cell senescence and TGF-beta signalling in atherosclerosis and peripheral arterial diseaseClaudio Raimondi
£291,075 British Heart Foundation
01-09-2016 - 31-08-2022