Dlk1 is a novel adrenocortical stem/progenitor cell marker that predicts malignancy in adrenocortical carcinoma
Mariniello K, Pittaway JFH, Altieri B, Borges KS, Hadjidemetriou I, Ribeiro C, Ruiz‐Babot G, Tourigny DS, Lim JA, Foster J, Cleaver J, Sosabowski J, Rahman N, Doroszko M, Hantel C, Sigala S, Abate A, Tamburello M, Kiseljak‐Vassiliades K, Wierman M, Hall C, Parvanta L, Abdel‐Aziz TE, Chung T, Di Marco A, Palazzo F, Gomez‐Sanchez CE, Taylor DR, Rayner O and Ronchi CL
Cancer Communications, Wiley 
04-03-2025

Senescent endothelial cells promote pathogenic neutrophil trafficking in inflamed tissues
Rolas L, Stein M, Barkaway A, Reglero-Real N, Sciacca E, Yaseen M, Wang H, Vazquez-Martinez L, Golding M, Blacksell IA, Giblin MJ, Jaworska E, Bishop CL, Voisin M-B, Gaston-Massuet C, Fossati-Jimack L, Pitzalis C, Cooper D, Nightingale TD, Lopez-Otin C, Lewis MJ and Nourshargh S
Embo Reports, Springer Nature vol. 25 (9), 3842-3869.  
25-06-2024

Correction: RET signalling provides tumorigenic mechanism and tissue specificity for AIP-related somatotrophinomas
Garcia-Rendueles AR, Chenlo M, Oroz-Gonjar F, Solomou A, Mistry A, Barry S, Gaston-Massuet C, Garcia-Lavandeira M, Perez-Romero S, Suarez-Fariña M, Pradilla-Dieste A, Dieguez C, Mehlen P, Korbonits M and Alvarez CV
Oncogene, Springer Nature vol. 42 (49), 3655-3656.  
06-11-2023

Imprinted Dlk1 dosage as a size determinant of the mammalian pituitary gland
Scagliotti V, Vignola ML, Willis T, Howard M, Marinelli E, Gaston-Massuet C, Andoniadou C and Charalambous M
Elife, Elife vol. 12 
17-08-2023

Dual mechanism underlying failure of neural tube closure in the Zic2 mutant mouse.
Escuin S, Rose Raza-Knight S, Savery D, Gaston-Massuet C, Galea GL, Greene NDE and Copp AJ
Disease Models & Mechanisms vol. 16 (3) 
01-03-2023

Phosphorylation of β-catenin at Serine552 correlates with invasion and recurrence of non-functioning pituitary neuroendocrine tumours
Rai A, Yelamanchi SD, Radotra BD, Gupta SK, Mukherjee KK, Tripathi M, Chhabra R, Ahuja CK, Kumar N, Pandey A, Korbonits M, Dutta P and Gaston-Massuet C
Acta Neuropathologica Communications, Springer Nature vol. 10 (1) 
16-09-2022

The imprinted Zdbf2 gene finely tunes control of feeding and growth in neonates
Glaser J, Iranzo J, Borensztein M, Marinucci M, Gualtieri A, Jouhanneau C, Teissandier A, Gaston-Massuet C and Bourc'his D
Elife, Elife vol. 11 
20-01-2022

RET signalling provides tumorigenic mechanism and tissue specificity for AIP-related somatotrophinomas
Garcia-Rendueles AR, Chenlo M, Oroz-Gonjar F, Solomou A, Mistry A, Barry S, Gaston-Massuet C, Garcia-Lavandeira M, Perez-Romero S, Suarez-Fariña M, Pradilla-Dieste A, Dieguez C, Mehlen P, Korbonits M and Alvarez CV
Oncogene, Springer Nature vol. 40 (45), 6354-6368.  
29-09-2021

WNT3A-loaded exosomes enable cartilage repair
Thomas B, Eldridge S, Nosrati B, Alvarez M, THORUP A-S, Nalesso G, Caxaria S, Barawi A, Nicholson J, Perretti M, Gaston-Massuet C, Pitzalis C, Maloney A, Moore A, Jupp R and Dell'Accio F
Journal of Extracellular Vesicles, Co-Action Publishing 
19-05-2021

Dysgenesis and Dysfunction of the Pancreas and Pituitary Due to FOXA2 Gene Defects
Kaygusuz SB, Ates EA, Vignola ML, Volkan B, Geckinli BB, Turan S, Bereket A, Gaston-Massuet C and Guran T
The Journal of Clinical Endocrinology & Metabolism, The Endocrine Society vol. 106 (10), e4142-e4154.  
17-05-2021

FOXA2 as a Candidate Gene Responsible for Congenital Panhypopituitarism: A Review of the Literature
Correia JC, Corral LG, Kaygusuz SB, Gualtieri A and Gaston-Massuet C
Journal of The Endocrine Society, The Endocrine Society vol. 5 (Supplement_1), a529-a529.  
03-05-2021

Activating mutations in BRAF disrupt the hypothalamo-pituitary axis leading to hypopituitarism in mice and humans
Gualtieri A, Kyprianou N, Gregory LC, Vignola ML, Nicholson JG, Tan R, Inoue S-I, Scagliotti V, Casado P, Blackburn J, Abollo-Jimenez F, Marinelli E, Besser REJ, Högler W, Karen Temple I, Davies JH, Gagunashvili A, Robinson ICAF, Camper SA, Davis SW, Cutillas PR, Gevers EF, Aoki Y, Dattani MT and Gaston-Massuet C
Nature Communications, Springer Nature vol. 12 (1) 
01-04-2021

Profiling the eicosanoid networks that underlie the anti- and pro-thrombotic effects of aspirin
Crescente M, Armstrong PC, Kirkby NS, Edin ML, Chan MV, Lih FB, Jiao J, Maffucci T, Allan HE, Mein CA, Gaston-Massuet C, Cottrell GS, Mitchell JA, Zeldin DC, Herschman HR and Warner TD
The Faseb Journal, Wiley Periodicals Llc 
27-06-2020

A Novel SEMA3G Mutation in Two Siblings Affected by Syndromic GnRH Deficiency
Oleari R, André V, Lettieri A, Tahir S, Roth L, Paganoni A, Eberini I, Parravicini C, Scagliotti V, Cotellessa L, Bedogni F, De Martini LB, Corridori MV, Gulli S, Augustin HG, Gaston-Massuet C, Hussain K and Cariboni A
Neuroendocrinology, Karger Publishers vol. 111 (5), 421-441.  
04-05-2020

A novel clinical risk score that accurately predicts recurrence of craniopharyngioma - a multicentre cohort study
Kyprianou N, Blackburn J, Tan R, Korbonits M, Dattani M, Dutta P, Bhansali A, Rai A, Ribalta T, Bulfamante GP, Massa V, Roncaroli F, Evanson J, Skoric T, Kastelan D, Gnanalingham K, Mitchell R, Bulfamante AM, Argente J, Goycoolea A, Torales J, Biagetti B, Audi L, Resmini E, Webb SM, Kapoor RR, Chandler C, Sampron N, Preda C and Ahmad A
Endocrine Abstracts, Bioscientifica 
11-11-2019

Stem Cells, Self-Renewal, and Lineage Commitment in the Endocrine System
Mariniello K, Ruiz-Babot G, McGaugh EC, Nicholson JG, Gualtieri A, Gaston-Massuet C, Nostro MC and Guasti L
Frontiers in Endocrinology, Frontiers vol. 10 
08-11-2019

Transcriptomic analyses reveal deregulation of focal adhesion pathway in Aip KO mice and AIP mutation positive human tumours
Bollington M, Mistry A, Solomou A, Barry S, Begalli F, Vignola M, Lim CT, Herincs M, Roncaroli F, Gaston-Massuet C and Korbonits M
Endocrine Abstracts, Bioscientifica 
06-11-2019

Investigating the role of AIP in pituitary tumourigenesis
Mistry A, Solomou A, Vignola ML, Lim CT, Herincs M, Caimari F, Costa AI, Begalli F, Gualtieri A, Roncaroli F, Rizzoti K, Gaston-Massuet C and Korbonits M
Endocrine Abstracts, Bioscientifica 
06-11-2019

Cell-Specific Gene Deletion Reveals the Antithrombotic Function of COX1 and Explains the Vascular COX1/Prostacyclin Paradox
Mitchell JA, Shala F, Elghazouli Y, Warner TD, Gaston-Massuet C, Crescente M, Armstrong PC, Herschman HR and Kirkby NS
Circulation Research, American Heart Association vol. 125 (9), 847-854.  
12-09-2019

Pathogenic variants in PLOD3 result in a Stickler syndrome-like connective tissue disorder with vascular complications
Ewans LJ, Colley A, Gaston-Massuet C, Gualtieri A, Cowley MJ, McCabe MJ, Anand D, Lachke SA, Scietti L, Forneris F, Zhu Y, Ying K, Walsh C, Kirk EP, Miller D, Giunta C, Sillence D, Dinger M, Buckley M and Roscioli T
Journal of Medical Genetics, Bmj vol. 56 (9) 
25-05-2019

Constitutive Activation of β-Catenin in Conventional Dendritic Cells Increases the Insulin Reserve to Ameliorate the Development of Type 2 Diabetes in Mice
Macdougall CE, Wood EG, Solomou A, Scagliotti V, Taketo MM, Gaston-Massuet C, Marelli-Berg FM, Charalambous M and Longhi MP
Diabetes, American Diabetes Association vol. 68 (7), 1473-1484.  
02-05-2019

Impaired EIF2S3 function associated with a novel phenotype of X-linked hypopituitarism with glucose dysregulation
Gregory LC, Ferreira CB, Young-Baird SK, Williams HJ, Harakalova M, van Haaften G, Rahman SA, Gaston-Massuet C, Kelberman D, GOSgene , Qasim W, Camper SA, Dever TE, Shah P, Robinson ICAF and Dattani MT
Ebiomedicine, Elsevier vol. 42, 470-480.  
14-03-2019

Tumor microenvironment defines the invasive phenotype of AIP-mutation-positive pituitary tumors
Barry S, Carlsen E, Marques P, Stiles CE, Gadaleta E, Berney DM, Roncaroli F, Chelala C, Solomou A, Herincs M, Caimari F, Grossman AB, Crnogorac-Jurcevic T, Haworth O, Gaston-Massuet C and Korbonits M
Oncogene, Springer Nature vol. 38 (27), 5381-5395.  
12-03-2019

Visceral Adipose Tissue Immune Homeostasis Is Regulated by the Crosstalk between Adipocytes and Dendritic Cell Subsets
Macdougall CE, Wood EG, Loschko J, Scagliotti V, Cassidy FC, Robinson ME, Feldhahn N, Castellano L, Voisin M-B, Marelli-Berg F, Gaston-Massuet C, Charalambous M and Longhi MP
Cell Metabolism, Elsevier vol. 27 (3), 588-601.e4.  
01-03-2018

Rings and Bricks: Expression of Cohesin Components is Dynamic during Development and Adult Life
Bettini LR, Graziola F, Fazio G, Grazioli P, Scagliotti V, Pasquini M, Cazzaniga G, Biondi A, Larizza L, Selicorni A, Gaston-Massuet C and Massa V
International Journal of Molecular Sciences, Mdpi vol. 19 (2) 
01-02-2018

The MAPK effector B-Raf is essential for hypothalamic-pituitary axis development and activating mutations in BRAF Cause Congenital hypopituitarism
Kyprianou N, Gregory L, Vignola ML, Marinelli E, Gualtieri A, Scagliotti V, Davis S, Casado P, Rajeeve V, Cutillas P, Gevers E, Dattani M and Gaston-Massuet C
Endocrine Abstracts, Bioscientifica 
30-10-2017

Novel FOXA2 mutation causes hyperinsulinism, hypopituitarism with craniofacial dysmorphism and endoderm-derived organ abnormalities
Giri D, Vignola ML, Gualtieri A, Scagliotti V, McNamara P, Peak M, Didi M, Gaston-Massuet C and Senniappan S
Endocrine Abstracts, Bioscientifica 
30-10-2017

Investigating the role of AIP in mouse pituitary adenoma formation
Solomou A, Herincs M, Roncaroli F, Vignola ML, Gaston-Massuet C and Korbonits M
Endocrine Abstracts, Bioscientifica 
20-10-2017

A comprehensive analysis of the AIP mutation positive pituitary tumour microenvironment: role of stromal cells and the pro-inflammatory cytokine network
Barry S, Solomou A, Vignola L, Collier D, Carlsen E, Gadaleta E, Berney DM, Chelala C, Crnogorac-Jurcevic T, Gaston-Massuet C and Korbonits M
Endocrine Abstracts, Bioscientifica 
20-10-2017

The MAPK effector B-Raf is essential for hypothalamic-pituitary axis development and activating mutations in BRAF cause congenital hypopituitarism
Kyprianou N, Gregory L, Lillina VM, Besser R, Marinelli E, Gualtieri A, Scagliotti V, Davis S, Gevers E, Dattani M and Gaston-Massuet C
Endocrine Abstracts, Bioscientifica 
20-10-2017

Novel FOXA2 mutation causes Hyperinsulinism, Hypopituitarism with Craniofacial and Endoderm-derived organ abnormalities
Giri D, Vignola ML, Gualtieri A, Scagliotti V, McNamara P, Peak M, Didi M, Gaston-Massuet C and Senniappan S
Human Molecular Genetics, Oxford University Press (Oup) vol. 26 (22), 4315-4326.  
24-08-2017

Ephrin-B2 is required for pituitary development
Jimenez F, Gualtieri A, Scagliotti V and Gaston-Massuet C
Endocrine Abstracts, Bioscientifica 
03-05-2017

Transcription factor 7-like 1 is involved in hypothalamo–pituitary axis development in mice and humans
Gaston-Massuet C, McCabe MJ, Scagliotti V, Young RM, Carreno G, Gregory LC, Jayakody SA, Pozzi S, Gualtieri A, Basu B, Koniordou M, Wu C-I, Bancalari RE, Rahikkala E, Veijola R, Lopponen T, Graziola F, Turton J, Signore M, Gharavy SNM, Charolidi N, Sokol SY, Andoniadou CL, Wilson SW, Merrill BJ, Dattani MT and Martinez-Barbera JP
Proceedings of The National Academy of Sciences of The United States of America, Proceedings of The National Academy of Sciences vol. 113 (5), e548-e557.  
13-01-2016

Cell death and cell proliferation in human spina bifida
Avagliano L, Doi P, Tosi D, Scagliotti V, Gualtieri A, Gaston-Massuet C, Pistocchi A, Gallina A, Marconi AM, Bulfamante G and Massa V
Birth Defects Research Part a Clinical and Molecular Teratology, Wiley vol. 106 (2), 104-113.  
10-12-2015

CyclinD1 Down‐Regulation and Increased Apoptosis Are Common Features of Cohesinopathies
Fazio G, Gaston-Massuet C, Bettini LR, Graziola F, Scagliotti V, Cereda A, Ferrari L, Mazzola M, Cazzaniga G, Giordano A, Cotelli F, Bellipanni G, Biondi A, Selicorni A, Pistocchi A and Massa V
Journal of Cellular Physiology, Wiley vol. 231 (3), 613-622.  
23-11-2015

Novel application of luciferase assay for the in vitro functional assessment of KAL1 variants in three females with septo-optic dysplasia (SOD)
McCabe MJ, Hu Y, Gregory LC, Gaston-Massuet C, Alatzoglou KS, Saldanha JW, Gualtieri A, Thankamony A, Hughes I, Townshend S, Martinez-Barbera J-P, Bouloux P-M and Dattani MT
Molecular and Cellular Endocrinology, Elsevier vol. 417, 63-72.  
14-09-2015

Histopathology and molecular characterisation of intrauterine-diagnosed congenital craniopharyngioma
Scagliotti V, Avagliano L, Gualtieri A, Graziola F, Doi P, Chalker J, Righini A, Korbonits M, Bulfamante G, Jacques TS, Massa V and Gaston-Massuet C
Pituitary, Springer Nature vol. 19 (1), 50-56.  
09-09-2015

The role of the sonic hedgehog signalling pathway in patients with midline defects and congenital hypopituitarism.
Gregory LC, Gaston-Massuet C, Andoniadou CL, Carreno G, Webb EA, Kelberman D, McCabe MJ, Panagiotakopoulos L, Saldanha JW, Spoudeas HA, Torpiano J, Rossi M, Raine J, Canham N, Martinez-Barbera JP and Dattani MT
Clin Endocrinol (Oxf) vol. 82 (5), 728-738.  
01-05-2015

Pituitary and Neuroendocrinology
Gevers EF, Gaston-Massuet C and de Roux N
In Yearbook of Pediatric Endocrinology 2014, Karger Publishers 1-14.  
01-08-2014

Sox2(+) stem/progenitor cells in the adult mouse pituitary support organ homeostasis and have tumor-inducing potential.
Andoniadou CL, Matsushima D, Mousavy Gharavy SN, Signore M, Mackintosh AI, Schaeffer M, Gaston-Massuet C, Mollard P, Jacques TS, Le Tissier P, Dattani MT, Pevny LH and Martinez-Barbera JP
Cell Stem Cell vol. 13 (4), 433-445.  
03-10-2013

Pituitary
Gevers EF, Gaston-Massuet C and Dattani MT
In Yearbook of Pediatric Endocrinology 2013, Karger Publishers 13-30.  
01-09-2013

Variations in PROKR2, but not PROK2, are associated with hypopituitarism and septo-optic dysplasia.
McCabe MJ, Gaston-Massuet C, Gregory LC, Alatzoglou KS, Tziaferi V, Sbai O, Rondard P, Masumoto K-H, Nagano M, Shigeyoshi Y, Pfeifer M, Hulse T, Buchanan CR, Pitteloud N, Martinez-Barbera J-P and Dattani MT
J Clin Endocrinol Metab vol. 98 (3), E547-E557.  
01-03-2013

SOX2 regulates the hypothalamic-pituitary axis at multiple levels.
Jayakody SA, Andoniadou CL, Gaston-Massuet C, Signore M, Cariboni A, Bouloux PM, Le Tissier P, Pevny LH, Dattani MT and Martinez-Barbera JP
J Clin Invest vol. 122 (10), 3635-3646.  
01-10-2012

Pituitary
Gevers EF, Gaston-Massuet C and Dattani MT
In Yearbook of Pediatric Endocrinology 2012, Karger Publishers 13-28.  
11-09-2012

Identification of novel pathways involved in the pathogenesis of human adamantinomatous craniopharyngioma.
Andoniadou CL, Gaston-Massuet C, Reddy R, Schneider RP, Blasco MA, Le Tissier P, Jacques TS, Pevny LH, Dattani MT and Martinez-Barbera JP
Acta Neuropathol vol. 124 (2), 259-271.  
01-08-2012

HESX1- and TCF3-mediated repression of Wnt/β-catenin targets is required for normal development of the anterior forebrain.
Andoniadou CL, Signore M, Young RM, Gaston-Massuet C, Wilson SW, Fuchs E and Martinez-Barbera JP
Development vol. 138 (22), 4931-4942.  
01-11-2011

Novel FGF8 mutations associated with recessive holoprosencephaly, craniofacial defects, and hypothalamo-pituitary dysfunction.
McCabe MJ, Gaston-Massuet C, Tziaferi V, Gregory LC, Alatzoglou KS, Signore M, Puelles E, Gerrelli D, Farooqi IS, Raza J, Walker J, Kavanaugh SI, Tsai P-S, Pitteloud N, Martinez-Barbera J-P and Dattani MT
J Clin Endocrinol Metab vol. 96 (10), E1709-E1718.  
01-10-2011

Increased Wingless (Wnt) signaling in pituitary progenitor/stem cells gives rise to pituitary tumors in mice and humans.
GASTON MASSUET JC, Andoniadou CL, Signore M, Jayakody SA, Charolidi N, Kyeyune R, Vernay B, Jacques TS, Taketo MM, Le Tissier P, Dattani MT and Martinez-Barbera JP
Proc Natl Acad Sci U S a. vol. 108 (28), 11482-11487.  
01-01-2011

ASPP2 Binds Par-3 and Controls the Polarity and Proliferation of Neural Progenitors during CNS Development
Sottocornola R, Royer C, Vives V, Tordella L, Zhong S, Wang Y, Ratnayaka I, Shipman M, Cheung A, Gaston-Massuet C, Ferretti P, Molnar Z and Lu X
Developmental Cell vol. 19 (1), 126-137.  
01-01-2010

Absence of SIX3 mutations in patients with congenital hypopituitarism.
Gaston-Massuet C, Kelberman D, Dattani M and Martinez-Barbera JP
Am J Med Genet A vol. 149A (12), 2874-2876.  
01-12-2009

Abstracts of papers presented at the nineteenth Genetics Society's Mammalian Genetics and Development Workshop held at the Institute of Child Health, University College London on 20 and 21 November 2008
GREENE NDE, COPP AJ, PAUWS E, STANIER P, PHILPOTT A, BROS V, FLENNIKEN A, SCHIAVO G, FISHER E, GREENSMITH L, HAFEZPARAST M, YU W-Y, MILETICH I, BUCHNER G, SHARPE PT, DE CASTRO SCP, SAVERY D, GUSTAVSSON P, LEUNG K-Y, FIELD S, BOGANI D, SIGGERS P, GREENFIELD A, NORRIS D, YAGUCHI Y, YU T, AHMED MU and GAIT M
Genetics Research, Hindawi vol. 91 (2), 133-141.  
01-04-2009

Role of Zic2 in mammalian neural tube closure
Massa V, Ybot-Gonzalez P, Savery D, Gaston-Massuet C, Greene NE and Copp AJ
Genetics Research vol. 91 (2), 140-140.  
01-01-2009

Genetic interaction between the homeobox transcription factors HESX1 and SIX3 is required for normal pituitary development.
Gaston-Massuet C, Andoniadou CL, Signore M, Sajedi E, Bird S, Turner JMA and Martinez-Barbera JP
Dev Biol vol. 324 (2), 322-333.  
15-12-2008

Analysis of mouse models carrying the I26T and R160C substitutions in the transcriptional repressor HESX1 as models for septo-optic dysplasia and hypopituitarism.
Sajedi E, Gaston-Massuet C, Signore M, Andoniadou CL, Kelberman D, Castro S, Etchevers HC, Gerrelli D, Dattani MT and Martinez-Barbera JP
Dis Model Mech vol. 1 (4-5), 241-254.  
01-01-2008

DNMT1 interacts with the developmental transcriptional repressor HESX1.
Sajedi E, Gaston-Massuet C, Andoniadou CL, Signore M, Hurd PJ, Dattani M and Martinez-Barbera JP
Biochim Biophys Acta vol. 1783 (1), 131-143.  
01-01-2008

Neural plate morphogenesis during mouse neurulation is regulated by antagonism of Bmp signalling.
Ybot-Gonzalez P, Gaston-Massuet C, Girdler G, Klingensmith J, Arkell R, Greene NDE and Copp AJ
Development vol. 134 (17), 3203-3211.  
01-09-2007

Abstracts of papers presented at the seventeenth Genetics Society's Mammalian Genetics and Development Workshop held at the Institute of Child Health, University College London on 9 and 10 November 2006
ROMIO L, CASTRO S, LOPES C, HAMES R, FEATHER SA, FRY AM, WILSON SW, WOOLF AS, STEVENS J, ERMAKOV A, BRAGANCA J, HILTON H, UNDERHILL P, BHATTACHARYA S, BROWN N, NORRIS D, SEPPALA M, FAN C-M, DEPEW M, SHARPE P, COBOURNE M, ANDONIADOU C, SIGNORE M, SAJEDI E, GASTON-MASSUET C, BARBERA JPM, COMPAGNUCCI C, DEPEW MJ, CATON J and ZOUPPA M
Genetics Research, Hindawi vol. 89 (3), 181-188.  
01-06-2007

Lack of the murine homeobox gene Hesx1 leads to a posterior transformation of the anterior forebrain.
Andoniadou CL, Signore M, Sajedi E, Gaston-Massuet C, Kelberman D, Burns AJ, Itasaki N, Dattani M and Martinez-Barbera JP
Development vol. 134 (8), 1499-1508.  
01-04-2007

Zic4, a zinc-finger transcription factor, is expressed in the developing mouse nervous system.
Gaston-Massuet C, Henderson DJ, Greene NDE and Copp AJ
Dev Dyn vol. 233 (3), 1110-1115.  
01-07-2005

Disruption of scribble (Scrb1) causes severe neural tube defects in the circletail mouse.
Murdoch JN, Henderson DJ, Doudney K, Gaston-Massuet C, Phillips HM, Paternotte C, Arkell R, Stanier P and Copp AJ
Hum Mol Genet vol. 12 (2), 87-98.  
15-01-2003