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Dr Barrie Peck

Barrie Peck


Barts Cancer Institute, Department of Tumour Biology
Faculty of Medicine and Dentistry, Queen Mary University of London
+44 (0)20 7882 3558
ORCiD Google Scholar



We utilise multicellular spheroid models to recapitulate the unfavourable tumour microenvironment (TME) encountered in vivo. We are particularly interested in nutrient stress and cancer cell metabolism that take place with the TME.


Publications of specific relevance to Predictive in vitro Models


Heydt Q, Xintaropoulou C, Clear A, Austin M, Pislariu I, Miraki-Moud F, Cutillas P, Korfi K, Calaminici M, Cawthorn W, Suchacki K, Nagano A, Gribben JG, Smith M, Cavenagh JD, Oakervee H, Castleton A, Taussig D, Peck B, Wilczynska A, McNaughton L, Bonnet D, Mardakheh F and Wrench B (2021). Adipocytes disrupt the translational programme of acute lymphoblastic leukaemia to favour tumour survival and persistence. Nature Research (Part of Springer Nature)  Nature Communications  10.1038/s41467-021-25540-4
Peck B, Bland P, Mavrommati I, Muirhead G, Cottom H, Wai PT, Maguire SL, Barker HE, Morrison E, Kriplani D, Yu L, Gibson A, Falgari G, Brennan K, Farnie G, Buus R, Marlow R, Novo D, Knight E, Guppy N, Kolarevic D, Susnjar S, Milijic NM, Naidoo K, Gazinska P, Roxanis I, Pancholi S, Martin LA, Holgersen EM and Cheang MCU (2021). 3D functional genomics screens identify CREBBP as a targetable driver in aggressive triple-negative breast cancer. Cancer Research  vol. 81, (4) 847-859. 10.1158/0008-5472.CAN-20-1822


Kapara A, Vannini A and Peck B (2020). A micronutrient with major effects on cancer cell viability. Nature Research  Nature Metabolism  10.1038/s42255-020-0244-3


Peck B and Schulze A (2019). Lipid Metabolism at the Nexus of Diet and Tumor Microenvironment. Trends in Cancer  vol. 5, (11) 693-703. 10.1016/j.trecan.2019.09.007


Jones DT, Valli A, Haider S, Zhang Q, Smethurst EA, Schug ZT, Peck B, Aboagye EO, Critchlow SE, Schulze A, Gottlieb E, Wakelam MJO and Harris AL (2018). 3D Growth of Cancer Cells Elicits Sensitivity to Kinase Inhibitors but Not Lipid Metabolism Modifiers. American Association For Cancer Research  Molecular Cancer Therapeutics  vol. 18, (2) 376-388. 10.1158/1535-7163.MCT-17-0857
Miess H, Dankworth B, Gouw AM, Rosenfeldt M, Schmitz W, Jiang M, Saunders B, Howell M, Downward J, Felsher DW, Peck B and Schulze A (2018). The glutathione redox system is essential to prevent ferroptosis caused by impaired lipid metabolism in clear cell renal cell carcinoma. Oncogene  vol. 37, (40) 5435-5450. 10.1038/s41388-018-0315-z


Leonidou A, Peck B and Natrajan R (2017). Identification and validation of driver kinases from next-generation sequencing data. 10.1007/978-1-4939-7154-1_12


Morrison E, Wai P, Leonidou A, Bland P, Khalique S, Farnie G, Daley F, Peck B and Natrajan R (2016). Utilizing functional genomics screening to identify potentially novel drug targets in cancer cell spheroid cultures. Journal of Visualized Experiments  vol. 2016, (118) 1-8. 10.3791/54738
Maguire SL, Peck B, Wai PT, Campbell J, Barker H, Gulati A, Daley F, Vyse S, Huang P, Lord CJ, Farnie G, Brennan K and Natrajan R (2016). Three-dimensional modelling identifies novel genetic dependencies associated with breast cancer progression in the isogenic MCF10 model. Journal of Pathology  vol. 240, (3) 315-328. 10.1002/path.4778
Peck B and Schulze A (2016). Lipid desaturation – the next step in targeting lipogenesis in cancer? Febs Journal  2767-2778. 10.1111/febs.13681
Peck B, Schug ZT, Zhang Q, Dankworth B, Jones DT, Smethurst E, Patel R, Mason S, Jiang M, Saunders R, Howell M, Mitter R, Spencer-Dene B, Stamp G, McGarry L, James D, Shanks E, Aboagye EO, Critchlow SE, Leung HY, Harris AL, Wakelam MJO, Gottlieb E and Schulze A (2016). Inhibition of fatty acid desaturation is detrimental to cancer cell survival in metabolically compromised environments. Cancer Metab  vol. 4, 10.1186/s40170-016-0146-8


Lewis CA, Brault C, Peck B, Bensaad K, Griffiths B, Mitter R, Chakravarty P, East P, Dankworth B, Alibhai D, Harris AL and Schulze A (2015). SREBP maintains lipid biosynthesis and viability of cancer cells under lipid- and oxygen-deprived conditions and defines a gene signature associated with poor survival in glioblastoma multiforme. Oncogene  vol. 34, (40) 5128-5140. 10.1038/onc.2014.439
Schug ZT, Peck B, Jones DT, Zhang Q, Grosskurth S, Alam IS, Goodwin LM, Smethurst E, Mason S, Blyth K, McGarry L, James D, Shanks E, Kalna G, Saunders RE, Jiang M, Howell M, Lassailly F, Thin MZ, Spencer-Dene B, Stamp G, van den Broek NJF, Mackay G, Bulusu V, Kamphorst JJ, Tardito S, Strachan D, Harris AL, Aboagye EO and Critchlow SE (2015). Acetyl-CoA synthetase 2 promotes acetate utilization and maintains cancer cell growth under metabolic stress. Cancer Cell  vol. 27, (1) 57-71. 10.1016/j.ccell.2014.12.002


Bensaad K, Favaro E, Lewis CA, Peck B, Lord S, Collins JM, Pinnick KE, Wigfield S, Buffa FM, Li JL, Zhang Q, Wakelam MJO, Karpe F, Schulze A and Harris AL (2014). Fatty acid uptake and lipid storage induced by HIF-1α contribute to cell growth and survival after hypoxia-reoxygenation. Cell Reports  vol. 9, (1) 349-365. 10.1016/j.celrep.2014.08.056
Peck B and Schulze A (2014). Cholesteryl esters: Fueling the fury of prostate cancer. Cell Metabolism  vol. 19, (3) 350-352. 10.1016/j.cmet.2014.02.012
Schug Z, Peck B, Jones D, Zhang Q, Alam I, Witney T, Smethurst E, Grosskurth S, Harris A, Critchlow S, Aboagye E, Wakelam M, Schulze A and Gottlieb E (2014). Acetyl-coA synthetase 2 promotes acetate utilization and maintains cell growth under metabolic stress. Cancer & Metabolism  vol. 2, (Suppl 1) O9-O9. 10.1186/2049-3002-2-S1-O9


Peck B, Ferber EC and Schulze A (2013). Antagonism between FOXO and MYC regulates cellular powerhouse. Frontiers in Oncology  vol. 3 APR, 10.3389/fonc.2013.00096
Baenke F, Peck B, Miess H and Schulze A (2013). Hooked on fat: The role of lipid synthesis in cancer metabolism and tumour development. Dmm Disease Models and Mechanisms  vol. 6, (6) 1353-1363. 10.1242/dmm.011338
Griffiths B, Lewis CA, Bensaad K, Ros S, Zhang Q, Ferber EC, Konisti S, Peck B, Miess H, East P, Wakelam M, Harris AL and Schulze A (2013). Sterol regulatory element binding protein-dependent regulation of lipid synthesis supports cell survival and tumor growth. Cancer Metab  vol. 1, (1) 10.1186/2049-3002-1-3


Ferber EC, Peck B, Delpuech O, Bell GP, East P and Schulze A (2012). FOXO3a regulates reactive oxygen metabolism by inhibiting mitochondrial gene expression. Cell Death and Differentiation  vol. 19, (6) 968-979. 10.1038/cdd.2011.179


Peck B and Schulze A (2011). A role for the cancer-associated miR-106b~25 cluster in neuronal stem cells. Aging  vol. 3, (4) 329-331. 10.18632/aging.100302


Peck B, Chen CY, Ho KK, Di Fruscia P, Myatt SS, Charles Coombes R, Fuchter MJ, Hsiao CD and Lam EWF (2010). SIRT inhibitors induce cell death and p53 acetylation through targeting both SIRT1 and SIRT2. Molecular Cancer Therapeutics  vol. 9, (4) 844-855. 10.1158/1535-7163.MCT-09-0971
Kwok JMM, Peck B, Monteiro LJ, Schwenen HDC, Millour J, Coombes RC, Myatt SS and Lam EWF (2010). FOXM1 confers acquired cisplatin resistance in breast cancer cells. Molecular Cancer Research  vol. 8, (1) 24-34. 10.1158/1541-7786.MCR-09-0432


Francis RE, Myatt SS, Krol J, Hartman J, Peck B, McGovern UB, Wang J, Guest SK, Filipovic A, Gojis O, Palmieri C, Peston D, Shousha S, Yu Q, Sicinski P, Charles Coombes R and Lam EWF (2009). FoxM1 is a downstream target and marker of HER2 overexpression in breast cancer. International Journal of Oncology  vol. 35, (1) 57-68. 10.3892/ijo_00000313
McGovern UB, Francis RE, Peck B, Guest SK, Wang J, Myatt SS, Krol J, Kwok JMM, Polychronis A, Coombes RC and Lam EWF (2009). Gefitinib (Iressa) represses FOXM1 expression via FOXO3a in breast cancer. Molecular Cancer Therapeutics  vol. 8, (3) 582-591. 10.1158/1535-7163.MCT-08-0805