Dr Barrie Peck
ECR/Lecturer
Department of Tumour Biology, Barts Cancer Institute
Queen Mary University of London
Queen Mary University of London
Research
Interests
We utilise multicellular spheroid models to recapitulate the unfavourable tumour microenvironment (TME) encountered in vivo. We are particularly interested in nutrient stress and cancer cell metabolism that take place with the TME.Publications
2025
LIMD1 Loss Confers a GPX4-Dependent Cell State in Lung CancerSaha A, Grevitt P, Junior JM, Von Kriegsheim A, Shah K, Gao Z, Stockwell BR, Finch A et al.
In Cold Spring Harbor Laboratory
07-06-2025
2024
Stearoyl-CoA desaturase inhibition is toxic to acute myeloid leukemia displaying high levels of the de novo fatty acid biosynthesis and desaturationDembitz V, Lawson H, Burt R, Natani S, Philippe C, James SC, Atkinson S, Durko J et al.
Leukemia, Springer Science and Business Media Llc vol. 38 (11), 2395-2409.
26-08-2024
CREBBP histone acetyltransferase domain mutations predict response to mTOR inhibition in relapsed/refractory follicular lymphomaKumar EA, Korfi K, Bewicke‐Copley F, Close K, Heward J, Witzig T, Leukam M, Ansell S et al.
British Journal of Haematology, Wiley vol. 205 (5), 1804-1809.
26-08-2024
2023
Abstract B020: SF3B1 hotspot mutations confer sensitivity to PARP inhibition through a defective replication stress responseBland P, Saville H, Wai PT, Curnow L, Nieminuszczy J, Ravindran N, Barker HE, Wright J et al.
Molecular Cancer Therapeutics, American Association For Cancer Research (Aacr) vol. 22 (12_Supplement), B020-B020.
01-12-2023
SCD inhibition preferentially eradicates AML displaying high de novo fatty acid desaturation and synergizes with chemotherapyDembitz V, Lawson H, Burt R, Philippe C, James SC, Atkinson S, Durko J, Wang LM et al.
In Cold Spring Harbor Laboratory
05-08-2023
SF3B1 hotspot mutations confer sensitivity to PARP inhibition by eliciting a defective replication stress responseBland P, Saville H, Wai PT, Curnow L, Muirhead G, Nieminuszczy J, Ravindran N, John MB et al.
Nature Genetics, Springer Science and Business Media Llc vol. 55 (8), 1311-1323.
31-07-2023
TGFβ-mediated MMP13 secretion drives myoepithelial cell dependent breast cancer progressionGibson SV, Tomas Bort E, Rodríguez-Fernández L, Allen MD, Gomm JJ, Goulding I, auf dem Keller U, Agnoletto A et al.
Npj Breast Cancer, Springer Science and Business Media Llc vol. 9 (1)
02-03-2023
Abstract P6-10-05: Mutations in the RNA Splicing Factor SF3B1 drive endocrine therapy resistance and confer a targetable replication stress response defect through PARP inhibitionBland P, Saville H, Read A, Wai P, Muirhead G, Curnow L, Nieminuszczy J, Ravindran N et al.
Cancer Research, American Association For Cancer Research (Aacr) vol. 83 (5_Supplement)
01-03-2023
2022
Inhibition of Stearoyl-CoA Desaturase Has Anti-Leukemic Properties in Acute Myeloid LeukemiaDembitz V, Lawson H, Philippe C, Burt RJ, James S, Magee ASM, Woodley K, Durko J et al.
Blood, American Society of Hematology vol. 140 (Supplement 1), 3058-3060.
15-11-2022
2021
Adipocytes disrupt the translational programme of acute lymphoblastic leukaemia to favour tumour survival and persistenceHeydt Q, Xintaropoulou C, Clear A, Austin M, Pislariu I, Miraki-Moud F, Cutillas P, Korfi K et al.
Nature Communications, Springer Science and Business Media Llc vol. 12 (1)
17-09-2021
3D Functional Genomics Screens Identify CREBBP as a Targetable Driver in Aggressive Triple-Negative Breast CancerPeck B, Bland P, Mavrommati I, Muirhead G, Cottom H, Wai PT, Maguire SL, Barker HE et al.
Cancer Research, American Association For Cancer Research (Aacr) vol. 81 (4), 847-859.
15-02-2021
2020
A micronutrient with major effects on cancer cell viabilityKapara A, Vannini A, Peck B
Nature Metabolism, Springer Science and Business Media Llc vol. 2 (7), 564-565.
06-07-2020
2019
Lipid Metabolism at the Nexus of Diet and Tumor MicroenvironmentPeck B, Schulze A
Trends in Cancer, Elsevier Bv vol. 5 (11), 693-703.
01-11-2019
3D Growth of Cancer Cells Elicits Sensitivity to Kinase Inhibitors but Not Lipid Metabolism ModifiersJones DT, Valli A, Haider S, Zhang Q, Smethurst EA, Schug ZT, Peck B, Aboagye EO et al.
Molecular Cancer Therapeutics, American Association For Cancer Research (Aacr) vol. 18 (2), 376-388.
01-02-2019
2018
Abstract 788: Modeling tumor microenvironmental heterogeneity identifies CREBBP as a novel tumor suppressor in breast cancerPeck B, Bland PJ, Wai PT, Cottom H, Maguire SL, Morrison E, Barker HE, Kriplani D et al.
Cancer Research, American Association For Cancer Research (Aacr) vol. 78 (13_Supplement), 788-788.
01-07-2018
The glutathione redox system is essential to prevent ferroptosis caused by impaired lipid metabolism in clear cell renal cell carcinomaMiess H, Dankworth B, Gouw AM, Rosenfeldt M, Schmitz W, Jiang M, Saunders B, Howell M et al.
Oncogene, Springer Science and Business Media Llc vol. 37 (40), 5435-5450.
05-06-2018
2017
Abstract NTOC-093: SYNTHETIC LETHAL APPROACHES TO TARGET ARID1A DEFICIENT OVARIAN CANCERSKhalique S, Williamson CT, Pemberton H, Wai PT, Menon M, Brough R, Leonidou A, Peck B et al.
Clinical Cancer Research, American Association For Cancer Research (Aacr) vol. 23 (11_Supplement)
31-05-2017
Identification and Validation of Driver Kinases from Next-Generation Sequencing DataLeonidou A, Peck B, Natrajan R
, Springer New York, 179-195.
01-01-2017
2016
Utilizing Functional Genomics Screening to Identify Potentially Novel Drug Targets in Cancer Cell Spheroid CulturesMorrison E, Wai P, Leonidou A, Bland P, Khalique S, Farnie G, Daley F, Peck B et al.
Journal of Visualized Experiments, Myjove Corporation (118)
26-12-2016
Three‐dimensional modelling identifies novel genetic dependencies associated with breast cancer progression in the isogenicMaguire SL, Peck B, Wai PT, Campbell J, Barker H, Gulati A, Daley F, Vyse S et al.
The Journal of Pathology, Wiley vol. 240 (3), 315-328.
19-10-2016
Functional assessment of low-frequency mutations in breast cancerLeonidou A, Maguire SL, Wai PT, Huang P, Peck B, Natrajan RC
European Journal of Cancer, Elsevier Bv vol. 61, S17-S17.
01-07-2016
Modelling the tumour microenvironment and employing functional genomics identifies CREBBP as a novel tumour suppressor in triple negative breast cancersPeck B, Maguire S, Morrison E, Wai P, Natrajan R
European Journal of Cancer, Elsevier Bv vol. 61, S73-S74.
01-07-2016
Inhibition of fatty acid desaturation is detrimental to cancer cell survival in metabolically compromised environmentsPeck B, Schug ZT, Zhang Q, Dankworth B, Jones DT, Smethurst E, Patel R, Mason S et al.
Cancer &Amp; Metabolism, Springer Science and Business Media Llc vol. 4 (1)
01-04-2016
Lipid desaturation – the next step in targeting lipogenesis in cancer?Peck B, Schulze A
The Febs Journal, Wiley vol. 283 (15), 2767-2778.
11-03-2016
Abstract PR06: Modeling the tumor microenvironment to identify novel loss of function mutations in breast cancer progressionPeck B, Maguire S, Morrison E, Wai P, Natrajan R
Molecular Cancer Research, American Association For Cancer Research (Aacr) vol. 14 (2_Supplement), PR06-PR06.
01-02-2016
2015
SREBP maintains lipid biosynthesis and viability of cancer cells under lipid- and oxygen-deprived conditions and defines a gene signature associated with poor survival in glioblastoma multiformeLewis CA, Brault C, Peck B, Bensaad K, Griffiths B, Mitter R, Chakravarty P, East P et al.
Oncogene, Springer Science and Business Media Llc vol. 34 (40), 5128-5140.
26-01-2015
Acetyl-CoA Synthetase 2 Promotes Acetate Utilization and Maintains Cancer Cell Growth under Metabolic StressSchug ZT, Peck B, Jones DT, Zhang Q, Grosskurth S, Alam IS, Goodwin LM, Smethurst E et al.
Cancer Cell, Elsevier Bv vol. 27 (1), 57-71.
01-01-2015
2014
Fatty Acid Uptake and Lipid Storage Induced by HIF-1α Contribute to Cell Growth and Survival after Hypoxia-ReoxygenationBensaad K, Favaro E, Lewis CA, Peck B, Lord S, Collins JM, Pinnick KE, Wigfield S et al.
Cell Reports, Elsevier Bv vol. 9 (1), 349-365.
01-10-2014
Acetyl-coA synthetase 2 promotes acetate utilization and maintains cell growth under metabolic stressSchug Z, Peck B, Jones D, Zhang Q, Alam I, Witney T, Smethurst E, Grosskurth S et al.
Cancer &Amp; Metabolism, Springer Science and Business Media Llc vol. 2 (S1)
01-05-2014
Cholesteryl Esters: Fueling the Fury of Prostate CancerPeck B, Schulze A
Cell Metabolism, Elsevier Bv vol. 19 (3), 350-352.
01-03-2014
2013
Hooked on fat: the role of lipid synthesis in cancer metabolism and tumour developmentBaenke F, Peck B, Miess H, Schulze A
Disease Models &Amp; Mechanisms, The Company of Biologists vol. 6 (6), 1353-1363.
01-11-2013
Sterol regulatory element binding protein-dependent regulation of lipid synthesis supports cell survival and tumor growthGriffiths B, Lewis CA, Bensaad K, Ros S, Zhang Q, Ferber EC, Konisti S, Peck B et al.
Cancer &Amp; Metabolism, Springer Science and Business Media Llc vol. 1 (1)
23-01-2013
Antagonism between FOXO and MYC Regulates Cellular PowerhousePeck B, Ferber EC, Schulze A
Frontiers in Oncology, Frontiers Media Sa vol. 3
01-01-2013
2011
FOXO3a regulates reactive oxygen metabolism by inhibiting mitochondrial gene expressionFerber EC, Peck B, Delpuech O, Bell GP, East P, Schulze A
Cell Death &Amp; Differentiation, Springer Science and Business Media Llc vol. 19 (6), 968-979.
02-12-2011
A role for the cancer-associated miR-106b~25 cluster in neuronal stem cellsPeck B, Schulze A
Aging, Impact Journals, Llc vol. 3 (4), 329-331.
31-03-2011
2010
SIRT Inhibitors Induce Cell Death and p53 Acetylation through Targeting Both SIRT1 and SIRT2Peck B, Chen C-Y, Ho K-K, Di Fruscia P, Myatt SS, Coombes RC, Fuchter MJ, Hsiao C-D et al.
Molecular Cancer Therapeutics, American Association For Cancer Research (Aacr) vol. 9 (4), 844-855.
01-04-2010
FOXM1 Confers Acquired Cisplatin Resistance in Breast Cancer CellsKwok JM-M, Peck B, Monteiro LJ, Schwenen HDC, Millour J, Coombes RC, Myatt SS, Lam EW-F
Molecular Cancer Research, American Association For Cancer Research (Aacr) vol. 8 (1), 24-34.
17-01-2010
2009
FoxM1 is a downstream target and marker of HER2 overexpression in breast cancerFrancis RE, Myatt SS, Krol J, Hartman J, Peck B, McGovern UB, Wang J, Guest SK et al.
Int J Oncol vol. 35 (1), 57-68.
01-07-2009
Gefitinib (Iressa) represses FOXM1 expression via FOXO3a in breast cancerMcGovern UB, Francis RE, Peck B, Guest SK, Wang J, Myatt SS, Krol J, Kwok JMM et al.
Mol Cancer Ther vol. 8 (3), 582-591.
01-03-2009
Grants
Understanding and exploiting the PTEN driven alternative splicing programme in hypoxic tumoursPrabhakar Rajan, Faraz Mardakheh, Tyson Sharp and Barrie Peck
£275,356 Prostate Cancer UK
01-10-2023 - 30-09-2026
Understanding and exploiting Acetyl-CoA metabolism in Small Cell Lung CancerBarrie Peck
£1,114,914 CR-UK Cancer Research UK
01-02-2023 - 31-01-2029
Validation of the ribosome biogenesis GTPase LSG1 as a therapeutic target in cancerAndrew Finch, Barrie Peck and John Marshall
£74,736 Barts and the London Charity
01-12-2023 - 31-03-2025
Establishing DHCR24 as a novel actionable target in clear cell Renal Cell CarcinomaBarrie Peck and Andrew Finch
£74,341 Barts and the London Charity
01-06-2023 - 31-12-2024