Dr Sheetal Inamdar

Sheetal Inamdar

Post Doc Researcher

School of Engineering and Material Sciences
Queen Mary University of London


Cartilage biomechanics, SAXS, Collagen, Multi-scale modelling, Nanomechanics


I am interested in the age related mechanisms that lead to altered tissue structure and mechanics through nanomechanical changes in the collagen matrix. We utilise bovine cartilage to model targeted structural changes which are then probed using small angle X-ray diffraction combined with in-situ mechanics.


Publications of specific relevance to Predictive in vitro Models


Inamdar SR, Prévost S, Terrill NJ, Knight MM and Gupta HS (2021). Reversible changes in the 3D collagen fibril architecture during cyclic loading of healthy and degraded cartilage. Elsevier  Acta Biomaterialia  vol. 136, 314-326. 10.1016/j.actbio.2021.09.037
Fu S, Meng H, Inamdar S, Das B, Gupta H, Wang W, Thompson C and Knight M (2021). Activation of TRPV4 by mechanical, osmotic or pharmaceutical stimulation is anti-inflammatory blocking IL-1β mediated articular cartilage matrix destruction., Editors: Block JA. Elsevier  Osteoarthritis and Cartilage  10.1016/j.joca.2020.08.002
Gupta HS, Barbieri E, Inamdar SR and Mo J (2021). Chapter 2: Synchrotron X-ray Imaging Combined with Multiscale Modeling Applied to Biological Soft Tissues. Rsc Soft Matter  10.1039/9781839161124-00034


Inamdar SR, Barbieri E, Terrill NJ, Knight MM and Gupta HS (2019). Proteoglycan degradation mimics static compression by altering the natural gradients in fibrillar organisation in cartilage. Elsevier  Acta Biomaterialia  vol. 97, 437-450. 10.1016/j.actbio.2019.07.055


Inamdar SR, Knight DP, Terrill NJ, Karunaratne A, Cacho-Nerin F, Knight MM and Gupta HS (2017). The Secret Life of Collagen: Temporal Changes in Nanoscale Fibrillar Pre-Strain and Molecular Organization During Physiological Loading of Cartilage. Acs Nano  10.1021/acsnano.7b00563


Chen J, Irianto J, Inamdar S, Pravincumar P, Lee DA, Bader DL and Knight MM (2012). Cell mechanics, structure, and function are regulated by the stiffness of the three-dimensional microenvironment. Biophys J  vol. 103, (6) 1188-1197. 10.1016/j.bpj.2012.07.054