Dr Sheetal Inamdar
Post Doc Researcher
School of Engineering and Material Sciences
Queen Mary University of London
Queen Mary University of London
Research
Cartilage biomechanics, SAXS, Collagen, Multi-scale modelling, Nanomechanics
Interests
I am interested in the age related mechanisms that lead to altered tissue structure and mechanics through nanomechanical changes in the collagen matrix. We utilise bovine cartilage to model targeted structural changes which are then probed using small angle X-ray diffraction combined with in-situ mechanics.Publications
Publications of specific relevance to Predictive in vitro Models2021
Inamdar SR, Prévost S, Terrill NJ, Knight MM and Gupta HS (2021). Reversible changes in the 3D collagen fibril architecture during cyclic loading of healthy and degraded cartilage. Elsevier Acta Biomaterialia vol. 136, 314-326. 10.1016/j.actbio.2021.09.037Fu S, Meng H, Inamdar S, Das B, Gupta H, Wang W, Thompson C and Knight M (2021). Activation of TRPV4 by mechanical, osmotic or pharmaceutical stimulation is anti-inflammatory blocking IL-1β mediated articular cartilage matrix destruction., Editors: Block JA. Elsevier Osteoarthritis and Cartilage 10.1016/j.joca.2020.08.002Gupta HS, Barbieri E, Inamdar SR and Mo J (2021). Chapter 2: Synchrotron X-ray Imaging Combined with Multiscale Modeling Applied to Biological Soft Tissues. Rsc Soft Matter 10.1039/9781839161124-000342019
Inamdar SR, Barbieri E, Terrill NJ, Knight MM and Gupta HS (2019). Proteoglycan degradation mimics static compression by altering the natural gradients in fibrillar organisation in cartilage. Elsevier Acta Biomaterialia vol. 97, 437-450. 10.1016/j.actbio.2019.07.0552017
Inamdar SR, Knight DP, Terrill NJ, Karunaratne A, Cacho-Nerin F, Knight MM and Gupta HS (2017). The Secret Life of Collagen: Temporal Changes in Nanoscale Fibrillar Pre-Strain and Molecular Organization During Physiological Loading of Cartilage. Acs Nano 10.1021/acsnano.7b005632012
Chen J, Irianto J, Inamdar S, Pravincumar P, Lee DA, Bader DL and Knight MM (2012). Cell mechanics, structure, and function are regulated by the stiffness of the three-dimensional microenvironment. Biophys J vol. 103, (6) 1188-1197. 10.1016/j.bpj.2012.07.054