Dr Peter McCormick
Reader in Molecular Pharmacology
William Harvey Research Institute
Faculty of Medicine and Dentistry, Queen Mary University of London
Faculty of Medicine and Dentistry, Queen Mary University of London
Research
G-protein coupled receptors, Neurological diseases, Obesity, Drug discovery
Interests
We use induced pluripotent stem cells in 2D and 3D cultures to look for early molecular signatures and mechanisms of disease onset in degenerative diseases. We also use 3D cultures of tumour cell lines to identify novel targets of metastasis and tumour growth.Publications
Publications of specific relevance to Predictive in vitro Models
2023
Relton EL, Roth NJ, Yasa S, Kaleem A, Hermey G, Minnis CJ, Mole SE, Shelkovnikova T, Lefrancois S, McCormick PJ and Locker N (2023). The Batten disease protein CLN3 is important for stress granules dynamics and translational activity. Journal of Biological Chemistry vol. 299, (5) 10.1016/j.jbc.2023.104649
Gill AK, McCormick PJ, Sochart D and Nalesso G (2023). Wnt signalling in the articular cartilage: A matter of balance. International Journal of Experimental Pathology vol. 104, (2) 56-63. 10.1111/iep.12472
Bort ET, Joseph MD, Wang Q, Carter EP, Roth NJ, Gibson J, Samadi A, Kocher HM, Simoncelli S, McCormick PJ and Grose RP (2023). Purinergic GPCR-integrin interactions drive pancreatic cancer cell invasion. Elife Elife vol. 12, 10.7554/elife.86971
Andrews A, Cottrell E, Maharaj A, Ladha T, Williams J, Schilbach K, Kaisinger LR, Perry JRB, Metherell LA, McCormick PJ and Storr HL (2023). Characterization of dominant-negative growth hormone receptor variants reveals a potential therapeutic target for short stature. Oxford University Press (Oup) European Journal of Endocrinology vol. 188, (4) 353-365. 10.1093/ejendo/lvad039
2022
Hu X, Lin C, Xu Q, Zhou X, Zeng P, McCormick PJ, Jiang H, Li J and Zhang J (2022). Structural Basis for the Inhibition of Coronaviral Main Proteases by a Benzothiazole-Based Inhibitor. Viruses vol. 14, (9) 10.3390/v14092075
Li J, Lin C, Zhou X, Zhong F, Zeng P, McCormick PJ, Jiang H and Zhang J (2022). Structural Basis of Main Proteases of Coronavirus Bound to Drug Candidate PF-07304814. Journal of Molecular Biology vol. 434, (16) 10.1016/j.jmb.2022.167706
Farooq Z, Howell LA and McCormick PJ (2022). Probing GPCR Dimerization Using Peptides. Frontiers in Endocrinology vol. 13, 10.3389/fendo.2022.843770
Li J, Lin C, Zhou X, Zhong F, Zeng P, Yang Y, Zhang Y, Yu B, Fan X, McCormick PJ, Fu R, Fu Y, Jiang H and Zhang J (2022). Structural Basis of the Main Proteases of Coronavirus Bound to Drug Candidate PF-07321332. Journal of Virology vol. 96, (8) 10.1128/jvi.02013-21
Song X, Li J, Tian M, Zhu H, Hu X, Zhang Y, Cao Y, Ye H, McCormick PJ, Zeng B, Fu Y, Duan J and Zhang J (2022). Cryo-EM structure of mouse TRPML2 in lipid nanodiscs. Journal of Biological Chemistry vol. 298, (2) 10.1016/j.jbc.2021.101487
Chalhoub G and McCormick PJ (2022). Palmitoylation and G-protein coupled receptors. 10.1016/bs.pmbts.2022.09.002
Zhang Y, Gao H, Hu X, Wang Q, Zhong F, Zhou X, Lin C, Yang Y, Wei J, Du W, Huang H, Zhou H, He W, Zhang H, McCormick PJ, Fu J, Wang D, Fu Y, Lu X, Zhang T, Duan J, Qin B, Jiang H, Luo J, Chen Q, Luo Q, Cheng L and Zhang Z (2022). Structure-Based Discovery and Structural Basis of a Novel Broad-Spectrum Natural Product against the Main Protease of Coronavirus. Journal of Virology vol. 96, (1) 10.1128/JVI.01253-21
Gazzi T, Brennecke B, Atz K, Korn C, Sykes D, Forn-Cuni G, Pfaff P, Sarott RC, Westphal MV, Mostinski Y, Mach L, Wasinska-Kalwa M, Weise M, Hoare BL, Miljuš T, Mexi M, Roth N, Koers EJ, Guba W, Alker A, Rufer AC, Kusznir EA, Huber S, Raposo C, Zirwes EA, Osterwald A, Pavlovic A, Moes S, Beck J and Nettekoven M (2022). Detection of cannabinoid receptor type 2 in native cells and zebrafish with a highly potent, cell-permeable fluorescent probe. Chemical Science 10.1039/d1sc06659e
2021
Ciancetta A, Gill AK, Ding T, Karlov DS, Chalhoub G, McCormick PJ and Tikhonova IG (2021). Probe Confined Dynamic Mapping for G Protein-Coupled Receptor Allosteric Site Prediction. Acs Central Science vol. 7, (11) 1847-1862. 10.1021/acscentsci.1c00802
Joseph MD, Bort ET, Grose RP, McCormick PJ and Simoncelli S (2021). Quantitative Super-Resolution Imaging for the Analysis of GPCR Oligomerization. Mdpi Biomolecules vol. 11, (10) 10.3390/biom11101503
Costas-Insua C, Moreno E, Maroto IB, Ruiz-Calvo A, Bajo-Grañeras R, Martín-Gutiérrez D, Diez-Alarcia R, Teresa Vilaró M, Cortés R, García-Font N, Martín R, Espina M, Botta J, Ginés S, McCormick PJ, Sánchez-Prieto J, Galve-Roperh I, Mengod G, Urigüen L, Marsicano G, Bellocchio L, Canela EI, Casadó V, Rodríguez-Crespo I and Guzmán M (2021). Identification of bip as a cb1 receptor-interacting protein that fine-tunes cannabinoid signaling in the mouse brain. Journal of Neuroscience vol. 41, (38) 7924-7941. 10.1523/JNEUROSCI.0821-21.2021
Li J, Zhou X, Zhang Y, Zhong F, Lin C, McCormick PJ, Jiang F, Luo J, Zhou H, Wang Q, Fu Y, Duan J and Zhang J (2021). Crystal structure of SARS-CoV-2 main protease in complex with the natural product inhibitor shikonin illuminates a unique binding mode. Science Bulletin vol. 66, (7) 661-663. 10.1016/j.scib.2020.10.018
Israeli H, Degtjarik O, Fierro F, Chunilal V, Gill AK, Roth NJ, Botta J, Prabahar V, Peleg Y, Chan LF, Ben-Zvi D, McCormick PJ, Niv MY and Shalev-Benami M (2021). Structure reveals the activation mechanism of the MC4 receptor to initiate satiation signaling. American Association For The Advancement of Science (Aaas) Science vol. 372, (6544) 808-814. 10.1126/science.abf7958
2020
Carreira EM, Grether U, Sarott RC, Westphal MV, Pfaff P, Korn C, Sykes DA, Gazzi T, Brennecke B, Atz K, Weise M, Mostinski Y, Hompluem P, Koers E, Miljuš T, Roth NJ, Asmelash H, Vong MC, Piovesan J, Guba W, Rufer AC, Kusznir EA, Huber S, Raposo C, Zirwes EA, Osterwald A, Pavlovic A, Moes S, Beck J and Benito-Cuesta I (2020). Development of high-specificity fluorescent probes to enable cannabinoid type 2 receptor studies in living cells. Journal of The American Chemical Society vol. 142, (40) 16953-16964. 10.1021/jacs.0c05587
Zhou X, Zhong F, Lin C, Hu X, Zhang Y, Xiong B, Yin X, Fu J, He W, Duan J, Fu Y, Zhou H, McCormick PJ, Wang Q, Li J and Zhang J (2020). Structure of SARS-CoV-2 main protease in the apo state. Springer Science in China Series C: Life Sciences 10.1007/s11427-020-1791-3
Moreno-Delgado D, Puigdellívol M, Moreno E, Rodríguez-Ruiz M, Botta J, Gasperini P, Chiarlone A, Howell LA, Scarselli M, Casadó V, Cortés A, Ferré S, Guzmán M, Lluís C, Alberch J, Canela EI, Ginés S and McCormick PJ (2020). Modulation of dopamine D1 receptors via histamine H3 receptors is a novel therapeutic target for Huntington's disease. Elife vol. 9, 1-31. 10.7554/eLife.51093
Contino M and McCormick PJ (2020). Editorial: The Canonical and Non-Canonical Endocannabinoid System as a Target in Cancer and Acute and Chronic Pain. Frontiers in Pharmacology vol. 11, 10.3389/fphar.2020.00312
Lewis R, Li J, McCormick PJ, L-H Huang C and Jeevaratnam K (2020). Is the sigma-1 receptor a potential pharmacological target for cardiac pathologies? A systematic review. Ijc Heart and Vasculature vol. 26, 10.1016/j.ijcha.2019.100449
Botta J, Appelhans J and McCormick PJ (2020). Continuing challenges in targeting oligomeric GPCR-based drugs. 10.1016/bs.pmbts.2019.11.009
2019
Bridge T, Shaikh SA, Thomas P, Botta J, McCormick PJ and Sachdeva A (2019). Site-Specific Encoding of Photoactivity in Antibodies Enables Light-Mediated Antibody–Antigen Binding on Live Cells. Angewandte Chemie - International Edition vol. 58, (50) 17986-17993. 10.1002/anie.201908655
Bridge T, Shaikh SA, Thomas P, Botta J, McCormick PJ and Sachdeva A (2019). Site‐Specific Encoding of Photoactivity in Antibodies Enables Light‐Mediated Antibody–Antigen Binding on Live Cells. Wiley Angewandte Chemie vol. 131, (50) 18154-18161. 10.1002/ange.201908655
Botta J, Bibic L, Killoran P, McCormick PJ and Howell LA (2019). Design and development of stapled transmembrane peptides that disrupt the activity of G-protein coupled receptor oligomers. J Biol Chem 10.1074/jbc.RA119.009160
Blasco-Benito S, Moreno E, Seijo-Vila M, Tundidor I, Andradas C, Caffarel MM, Caro-Villalobos M, Urigüen L, Diez-Alarcia R, Moreno-Bueno G, Hernández L, Manso L, Homar-Ruano P, McCormick PJ, Bibic L, Bernadó-Morales C, Arribas J, Canals M, Casadó V, Canela EI, Guzmán M, Pérez-Gómez E and Sánchez C (2019). Therapeutic targeting of HER2–CB2R heteromers in HER2-positive breast cancer. Proceedings of The National Academy of Sciences of The United States of America vol. 116, (9) 3863-3872. 10.1073/pnas.1815034116
Blasco-Benito S, Moreno E, Seijo-Vila M, Tundidor I, Andradas C, Caffarel MM, Caro-Villalobos M, Urigüen L, Diez-Alarcia R, Moreno-Bueno G, Hernández L, Manso L, Homar-Ruano P, McCormick PJ, Bibic L, Bernadó-Morales C, Arribas J, Canals M, Casadó V, Canela EI, Guzmán M, Pérez-Gómez E and Sánchez C (2019). Erratum: Therapeutic targeting of HER2-CB2R heteromers in HER2-positive breast cancer (Proceedings of the National Academy of Sciences of the United States of America (2019) 116 (3863–3872) DOI: 10.1073/pnas.1815034116). Proceedings of The National Academy of Sciences of The United States of America vol. 116, (13) 10.1073/pnas.1903209116
2018
Aringhieri S, Carli M, Kolachalam S, Verdesca V, Cini E, Rossi M, McCormick PJ, Corsini GU, Maggio R and Scarselli M (2018). Molecular targets of atypical antipsychotics: From mechanism of action to clinical differences. Pharmacology and Therapeutics vol. 192, 20-41. 10.1016/j.pharmthera.2018.06.012
Navarro G, Cordomí A, Brugarolas M, Moreno E, Aguinaga D, Pérez-Benito L, Ferre S, Cortés A, Casadó V, Mallol J, Canela EI, Lluís C, Pardo L, McCormick PJ and Franco R (2018). Cross-communication between Gi and Gs in a G-protein-coupled receptor heterotetramer guided by a receptor C-terminal domain. Bmc Biology vol. 16, (1) 10.1186/s12915-018-0491-x
2017
García-Cárceles J, Decara JM, Vázquez-Villa H, Rodríguez R, Codesido E, Cruces J, Brea J, Loza MI, Alén F, Botta J, McCormick PJ, Ballesteros JA, Benhamú B, Rodríguez De Fonseca F and López-Rodríguez ML (2017). A Positive Allosteric Modulator of the Serotonin 5-HT2C Receptor for Obesity. Journal of Medicinal Chemistry vol. 60, (23) 9575-9584. 10.1021/acs.jmedchem.7b00994
Sauvageau E, McCormick PJ and Lefrancois S (2017). In vivo monitoring of the recruitment and activation of AP-1 by Arf1. Scientific Reports vol. 7, (1) 10.1038/s41598-017-07493-1
Fahradpour M, Keov P, Tognola C, Perez-Santamarina E, McCormick PJ, Ghassempour A and Gruber CW (2017). Cyclotides isolated from an ipecac root extract antagonize the corticotropin releasing factor type 1 receptor. Frontiers in Pharmacology vol. 8, (SEP) 10.3389/fphar.2017.00616
Rodríguez-Ruiz M, Moreno E, Moreno-Delgado D, Navarro G, Mallol J, Cortés A, Lluís C, Canela EI, Casadó V, McCormick PJ and Franco R (2017). Heteroreceptor Complexes Formed by Dopamine D1 , Histamine H3 , and N-Methyl-D-Aspartate Glutamate Receptors as Targets to Prevent Neuronal Death in Alzheimer’s Disease. Molecular Neurobiology vol. 54, (6) 4537-4550. 10.1007/s12035-016-9995-y
González-Vera JA, Medina RA, Martín-Fontecha M, Gonzalez A, De La Fuente T, Vázquez-Villa H, García-Cárceles J, Botta J, McCormick PJ, Benhamú B, Pardo L and López-Rodríguez ML (2017). A new serotonin 5-HT 6 receptor antagonist with procognitive activity - Importance of a halogen bond interaction to stabilize the binding. Scientific Reports vol. 7, 10.1038/srep41293
HOWELL LA, Moreno E, Chiarlone A, Medrano M, Puigdellívol M, Bibic L, Resel E, Puente N, Casarejos MJ, Perucho J, Botta J, Suelves N, Ciruela F, Ginés S, Galve-Roperh I, Casadó V, Grandes P, Lutz B, Monory K, Canela EI, Lluís C, McCormick PJ and Guzmán M (2017). Singular Location and Signaling Profile of Adenosine A2A-Cannabinoid CB1 Receptor Heteromers in the Dorsal Striatum. Nature Publishing Group Neuropsychopharmacology (Nature) 10.1038/npp.2017.12
McCormick PJ and Botta J (2017). Heteromers form novel signaling complexes. Receptors 10.1007/978-3-319-60174-8_19
Hoffmann HM, Crouzin N, Moreno E, Raivio N, Fuentes S, McCormick PJ, Ortiz J and Vignes M (2017). Long-lasting impairment of mGluR5 -activated intracellular pathways in the striatum after withdrawal of cocaine self-administration. International Journal of Neuropsychopharmacology vol. 20, (1) 72-82. 10.1093/ijnp/pyw086
2016
Hernandez-Garzón E, Fernandez AM, Perez-Alvarez A, Genis L, Bascuñana P, Fernandez de la Rosa R, Delgado M, Angel Pozo M, Moreno E, McCormick PJ, Santi A, Trueba-Saiz A, Garcia-Caceres C, Tschöp MH, Araque A, Martin ED and Torres Aleman I (2016). The insulin-like growth factor I receptor regulates glucose transport by astrocytes. Glia vol. 64, (11) 1962-1971. 10.1002/glia.23035
Busnelli M, Kleinau G, Muttenthaler M, Stoev S, Manning M, Bibic L, Howell LA, McCormick PJ, Di Lascio S, Braida D, Sala M, Rovati GE, Bellini T and Chini B (2016). Design and Characterization of Superpotent Bivalent Ligands Targeting Oxytocin Receptor Dimers via a Channel-Like Structure. Journal of Medicinal Chemistry vol. 59, (15) 7152-7166. 10.1021/acs.jmedchem.6b00564
Navarro G, Aguinaga D, Angelats E, Medrano M, Moreno E, Mallol J, Cortés A, Canela EI, Casadó V, McCormick PJ, Lluís C and Ferré S (2016). A significant role of the truncated ghrelin receptor GHS-R1b in ghrelin-induced signaling in neurons. Journal of Biological Chemistry vol. 291, (25) 13048-13062. 10.1074/jbc.M116.715144
Navarro G, Cordomí A, Zelman-Femiak M, Brugarolas M, Moreno E, Aguinaga D, Perez-Benito L, Cortés A, Casadó V, Mallol J, Canela EI, Lluís C, Pardo L, García-Sáez AJ, McCormick PJ and Franco R (2016). Quaternary structure of a G-protein-coupled receptor heterotetramer in complex with Gi and Gs . Bmc Biology vol. 14, (1) 10.1186/s12915-016-0247-4
Scarselli M, Annibale P, McCormick PJ, Kolachalam S, Aringhieri S, Radenovic A, Corsini GU and Maggio R (2016). Revealing G-protein-coupled receptor oligomerization at the single-molecule level through a nanoscopic lens: Methods, dynamics and biological function. Febs Journal vol. 283, (7) 1197-1217. 10.1111/febs.13577
Naval-Macabuhay I, Casanova V, Navarro G, García F, León A, Miralles L, Rovira C, Martinez-Navio JM, Gallart T, Mallol J, Gatell JM, Llúis C, Franco R, McCormick PJ and Climent N (2016). Adenosine deaminase regulates Treg expression in autologous T cell-dendritic cell cocultures from patients infected with HIV-1. Journal of Leukocyte Biology vol. 99, (2) 349-359. 10.1189/jlb.3A1214-580RR
2015
Marada S, Navarro G, Truong A, Stewart DP, Arensdorf AM, Nachtergaele S, Angelats E, Opferman JT, Rohatgi R, McCormick PJ and Ogden SK (2015). Functional Divergence in the Role of N-Linked Glycosylation in Smoothened Signaling. Plos Genetics vol. 11, (8) 10.1371/journal.pgen.1005473
Pérez-Gómez E, Andradas C, Blasco-Benito S, Caffarel MM, García-Taboada E, Villa-Morales M, Moreno E, Hamann S, Martín-Villar E, Flores JM, Wenners A, Alkatout I, Klapper W, Röcken C, Bronsert P, Stickeler E, Staebler A, Bauer M, Arnold N, Soriano J, Pérez-Martínez M, Megías D, Moreno-Bueno G, Ortega-Gutiérrez S, Artola M, Vázquez-Villa H, Quintanilla M, Fernández-Piqueras J, Canela EI and McCormick PJ (2015). Role of cannabinoid receptor CB2 in HER2 pro-oncogenic signaling in breast cancer. Journal of The National Cancer Institute vol. 107, (6) 10.1093/jnci/djv077
Navarro G, Quiroz C, Moreno-Delgado D, Sierakowiak A, McDowell K, Moreno E, Rea W, Cai NS, Aguinaga D, Howell LA, Hausch F, Cortés A, Mallol J, Casadó V, Lluís C, Canela EI, Ferré S and McCormick PJ (2015). Orexin–corticotropin-releasing factor receptor heteromers in the ventral tegmental area as targets for cocaine. Journal of Neuroscience vol. 35, (17) 6639-6653. 10.1523/JNEUROSCI.4364-14.2015
Viñals X, Moreno E, Lanfumey L, Cordomí A, Pastor A, De La Torre R, Gasperini P, Navarro G, Howell LA, Pardo L, Lluís C, Canela EI, McCormick PJ, Maldonado R and Robledo P (2015). Cognitive impairment induced by delta9- tetrahydrocannabinol occurs through heteromers between cannabinoid CB1 and serotonin 5-HT2A receptors. Plos Biology vol. 13, (7) 10.1371/journal.pbio.1002194
2014
Navarro G, Aguinaga D, Moreno E, Hradsky J, Reddy PP, Cortés A, Mallol J, Casadó V, Mikhaylova M, Kreutz MR, Lluís C, Canela EI, McCormick PJ and Ferré S (2014). Intracellular calcium levels determine differential modulation of allosteric interactions within G protein-coupled receptor heteromers. Chemistry and Biology vol. 21, (11) 1546-1556. 10.1016/j.chembiol.2014.10.004
Guitart X, Navarro G, Moreno E, Yano H, Cai NS, Sánchez-Soto M, Kumar-Barodia S, Naidu YT, Mallol J, Cortés A, Lluís C, Canela EI, Casadó V, McCormick PJ and Ferré S (2014). Functional selectivity of allosteric interactions within G protein-coupled receptor oligomers: The dopamine D1 -D3 receptor heterotetramer. Molecular Pharmacology vol. 86, (4) 417-429. 10.1124/mol.114.093096
Moreno E, Andradas C, Medrano M, Caffarel MM, Pérez-Gómez E, Blasco-Benito S, Gómez-Cañas M, Pazos MR, Irving AJ, Lluís C, Canela EI, Fernández-Ruiz J, Guzmán M, McCormick PJ and Sánchez C (2014). Targeting CB2 -GPR55 receptor heteromers modulates cancer cell signaling. Journal of Biological Chemistry vol. 289, (32) 21960-21972. 10.1074/jbc.M114.561761
Zhang Y, Calado R, Rao M, Hong JA, Meeker AK, Dumitriu B, Atay S, McCormick PJ, Garfield SH, Wangsa D, Padilla-Nash HM, Burkett S, Zhang M, Kunst TF, Peterson NR, Xi S, Inchauste S, Altorki NK, Casson AG, Beer DG, Harris CC, Ried T, Young NS and Schrump DS (2014). Telomerase variant A279T induces telomere dysfunction and inhibits non-canonical telomerase activity in esophageal carcinomas. Plos One vol. 9, (7) 10.1371/journal.pone.0101010
Bonaventura J, Rico AJ, Moreno E, Sierra S, Sánchez M, Luquin N, Farré D, Müller CE, Martínez-Pinilla E, Cortés A, Mallol J, Armentero MT, Pinna A, Canela EI, Lluís C, McCormick PJ, Lanciego JL, Casadó V and Franco R (2014). L-DOPA-treatment in primates disrupts the expression of A2A adenosine-CB1 cannabinoid-D2 dopamine receptor heteromers in the caudate nucleus. Neuropharmacology vol. 79, 90-100. 10.1016/j.neuropharm.2013.10.036
Moreno E, Moreno-Delgado D, Navarro G, Hoffmann HM, Fuentes S, Rosell-Vilar S, Gasperini P, Rodríguez-Ruiz M, Medrano M, Mallol J, Cortés A, Casadó V, Lluís C, Ferré S, Ortiz J, Canela E and McCormick PJ (2014). Cocaine disrupts histamine H3 receptor modulation of dopamine D1 receptor signaling: σ1 -D1 -H3 receptor complexes as key targets for reducing cocaine's effects. Journal of Neuroscience vol. 34, (10) 3545-3558. 10.1523/JNEUROSCI.4147-13.2014
Pinna A, Bonaventura J, Farré D, Sánchez M, Simola N, Mallol J, Lluís C, Costa G, Baqi Y, Müller CE, Cortés A, McCormick P, Canela EI, Martínez-Pinilla E, Lanciego JL, Casadó V, Armentero MT and Franco R (2014). L-DOPA disrupts adenosine A2A -cannabinoid CB1 -dopamine D2 receptor heteromer cross-talk in the striatum of hemiparkinsonian rats: Biochemical and behavioral studies. Experimental Neurology vol. 253, 180-191. 10.1016/j.expneurol.2013.12.021
2013
Cristóvão-Ferreira S, Navarro G, Brugarolas M, Pérez-Capote K, Vaz SH, Fattorini G, Conti F, Lluis C, Ribeiro JA, McCormick PJ, Casadó V, Franco R and Sebastião AM (2013). A1 R-A2A R heteromers coupled to Gs and Gi/0 proteins modulate GABA transport into astrocytes. Purinergic Signalling vol. 9, (3) 433-449. 10.1007/s11302-013-9364-5
Gracia E, Moreno E, Cortés A, Lluís C, Mallol J, McCormick PJ, Canela EI and Casadó V (2013). Homodimerization of adenosine A1 receptors in brain cortex explains the biphasic effects of caffeine. Neuropharmacology vol. 71, 56-69. 10.1016/j.neuropharm.2013.03.005
Navarro G, Moreno E, Bonaventura J, Brugarolas M, Farré D, Aguinaga D, Mallol J, Cortés A, Casadó V, Lluís C, Ferre S, Franco R, Canela E and McCormick PJ (2013). Cocaine Inhibits Dopamine D2 Receptor Signaling via Sigma-1-D2 Receptor Heteromers. Plos One vol. 8, (4) 10.1371/journal.pone.0061245
Gracia E, Farré D, Cortés A, Ferrer-Costa C, Orozco M, Mallol J, Lluís C, Canela EI, McCormick PJ, Franco R, Fanelli F and Casadó V (2013). The catalytic site structural gate of adenosine deaminase allosterically modulates ligand binding to adenosine receptors. Faseb Journal vol. 27, (3) 1048-1061. 10.1096/fj.12-212621
Franco R, Martínez-Pinilla E, Ricobaraza A and McCormick PJ (2013). Challenges in the development of heteromer-GPCR-based drugs. Progress in Molecular Biology and Translational Science 10.1016/B978-0-12-386931-9.00006-4
Navarro G, McCormick PJ, Mallol J, Lluís C, Franco R, Cortés A, Casadó V, Canela EI and Ferré S (2013). Detection of receptor heteromers involving dopamine receptors by the sequential BRET-FRET technology. Methods in Molecular Biology vol. 964, 95-105. 10.1007/978-1-62703-251-3_7
Franco R, Martínez-Pinilla E, Ricobaraza A and McCormick PJ (2013). Challenges in the development of heteromer-GPCR-based drugs. 10.1016/B978-0-12-386931-9.00006-4
2012
Casanova V, Naval-Macabuhay I, Massanella M, Rodríguez-García M, Blanco J, Gatell JM, García F, Gallart T, Lluis C, Mallol J, Franco R, Climent N and McCormick PJ (2012). Adenosine Deaminase Enhances the Immunogenicity of Human Dendritic Cells from Healthy and HIV-Infected Individuals. Plos One vol. 7, (12) 10.1371/journal.pone.0051287
Luquin N, Sierra S, Rico AJ, Gómez-Bautista V, Roda E, Conte-Perales L, Franco R, McCormick P, Labandeira-García JL and Lanciego JL (2012). Unmasking adenosine 2A receptors (A2A Rs) in monkey basal ganglia output neurons using cholera toxin subunit B (CTB). Neurobiology of Disease vol. 47, (3) 347-357. 10.1016/j.nbd.2012.05.006
Callén L, Moreno E, Barroso-Chinea P, Moreno-Delgado D, Cortés A, Mallol J, Casadó V, Lanciego JL, Franco R, Lluis C, Canela EI and McCormick PJ (2012). Cannabinoid receptors CB 1 and CB 2 form functional heteromers in brain. Journal of Biological Chemistry vol. 287, (25) 20851-20865. 10.1074/jbc.M111.335273
González S, Rangel-Barajas C, Peper M, Lorenzo R, Moreno E, Ciruela F, Borycz J, Ortiz J, Lluís C, Franco R, McCormick PJ, Volkow ND, Rubinstein M, Floran B and Ferré S (2012). Dopamine D 4 receptor, but not the ADHD-associated D 4.7 variant, forms functional heteromers with the dopamine D 2S receptor in the brain. Molecular Psychiatry vol. 17, (6) 650-662. 10.1038/mp.2011.93
Navarro G, Hradsky J, Lluís C, Casadó V, McCormick PJ, Kreutz MR and Mikhaylova M (2012). NCS-1 associates with adenosine A 2A receptors and modulates receptor function. Frontiers in Molecular Neuroscience (APRIL) 10.3389/fnmol.2012.00053
Gasperini P, Espigol-Frigole G, McCormick PJ, Salvucci O, Maric D, Uldrick TS, Polizzotto MN, Yarchoan R and Tosato G (2012). Kaposi sarcoma herpesvirus promotes endothelial-to-mesenchymal transition through notch-dependent signaling. Cancer Research vol. 72, (5) 1157-1169. 10.1158/0008-5472.CAN-11-3067
González S, Moreno-Delgado D, Moreno E, Pérez-Capote K, Franco R, Mallol J, Cortés A, Casadó V, Lluís C, Ortiz J, Ferré S, Canela E and McCormick PJ (2012). Circadian-related heteromerization of adrenergic and dopamine d4 receptors modulates melatonin synthesis and release in the pineal gland. Plos Biology vol. 10, (6) 10.1371/journal.pbio.1001347
2011
Cristóvão-Ferreira S, Navarro G, Brugarolas M, Pérez-Capote K, Vaz SH, Fattorini G, Conti F, Lluis C, Ribeiro JA, McCormick PJ, Casadó V, Franco R and Sebastião AM (2011). Modulation of GABA transport by adenosine A 1 R-A 2A R heteromers, which are coupled to both G s - and G i/o -Proteins. Journal of Neuroscience vol. 31, (44) 15629-15639. 10.1523/JNEUROSCI.2526-11.2011
Hradsky J, Raghuram V, Reddy PP, Navarro G, Hupe M, Casado V, McCormick PJ, Sharma Y, Kreutz MR and Mikhaylova M (2011). Post-translational membrane insertion of tail-anchored transmembrane EF-hand Ca 2+ sensor calneurons requires the TRC40/Asna1 protein chaperone. Journal of Biological Chemistry vol. 286, (42) 36762-36776. 10.1074/jbc.M111.280339
Moreno E, Vaz SH, Cai NS, Ferrada C, Quiroz C, Barodia SK, Kabbani N, Canela EI, McCormick PJ, Lluis C, Franco R, Ribeiro JA, Sebastião AM and Ferré S (2011). Dopamine-galanin receptor heteromers modulate cholinergic neurotransmission in the rat ventral hippocampus. Journal of Neuroscience vol. 31, (20) 7412-7423. 10.1523/JNEUROSCI.0191-11.2011
Vendrell M, Molero A, González S, Pérez-Capote K, Lluis C, McCormick PJ, Franco R, Cortés A, Casadó V, Albericio F and Royo M (2011). Biotin ergopeptide probes for dopamine receptors. Journal of Medicinal Chemistry vol. 54, (4) 1080-1090. 10.1021/jm101566d
Moreno E, Hoffmann H, Gonzalez-Sepúlveda M, Navarro G, Casadó V, Cortés A, Mallol J, Vignes M, McCormick PJ, Canela EI, Lluís C, Moratalla R, Ferré S, Ortiz J and Franco R (2011). Dopamine D1 -histamine H3 receptor heteromers provide a selective link to MAPK signaling in GABAergic neurons of the direct striatal pathway. Journal of Biological Chemistry vol. 286, (7) 5846-5854. 10.1074/jbc.M110.161489
2010
Navarro G, Moreno E, Aymerich M, Marcellino D, McCormick PJ, Mallol J, Cortésa A, Casadó V, Canela EI, Ortiz J, Fuxe K, Lluís C, Ferré S and Franco R (2010). Direct involvement of σ-1 receptors in the dopamine D1 receptor-mediated effects of cocaine. Proceedings of The National Academy of Sciences of The United States of America vol. 107, (43) 18676-18681. 10.1073/pnas.1008911107
De La Luz Sierra M, Sakakibara S, Gasperini P, Salvucci O, Jiang K, McCormick PJ, Segarra M, Stone J, Maric D, Zhu J, Qian X, Lowy DR and Tosato G (2010). The transcription factor Gfi1 regulates G-CSF signaling and neutrophil development through the Ras activator RasGRP1. Blood vol. 115, (19) 3970-3979. 10.1182/blood-2009-10-246967
2009
McCormick PJ, Segarra M, Gasperini P, Gulino AV and Tosato G (2009). Impaired recruitment of GrK6 and β-arrestin2 causes delayed internalization and desensitization of a WHIM syndrome-associated CXCR4 mutant receptor. Plos One vol. 4, (12) 10.1371/journal.pone.0008102
2008
McCormick PJ, Dumaresq-Doiron K, Pluviose AS, Pichette V, Tosato G and Lefrancois S (2008). Palmitoylation controls recycling in lysosomal sorting and trafficking. Traffic vol. 9, (11) 1984-1997. 10.1111/j.1600-0854.2008.00814.x
Segarra M, Williams CK, De La Luz Sierra M, Bernardo M, McCormick PJ, Maric D, Regino C, Choyke P and Tosato G (2008). DII4 activation of Notch signaling reduces tumor vascularity and inhibits tumor growth. Blood vol. 112, (5) 1904-1911. 10.1182/blood-2007-11-126045
Barral DC, Cavallari M, McCormick PJ, Garg S, Magee AI, Bonifacino JS, De Libero G and Brenner MB (2008). CD1a and MHC class I follow a similar endocytic recycling pathway. Traffic vol. 9, (9) 1446-1457. 10.1111/j.1600-0854.2008.00781.x
2007
Sierra MDLL, Gasperini P, McCormick PJ, Zhu J and Tosato G (2007). Transcription factor Gfi-1 induced by G-CSF is a negative regulator of CXCR4 in myeloid cells. Blood vol. 110, (7) 2276-2285. 10.1182/blood-2007-03-081448
Lefrançois S and McCormick PJ (2007). The Arf GEF GBF1 is required for GGA recruitment to Golgi membranes. Traffic vol. 8, (10) 1440-1451. 10.1111/j.1600-0854.2007.00623.x
Saurí A, McCormick PJ, Johnson AE and Mingarro I (2007). Sec61α and TRAM are Sequentially Adjacent to a Nascent Viral Membrane Protein during its ER Integration. Journal of Molecular Biology vol. 366, (2) 366-374. 10.1016/j.jmb.2006.11.052
2006
Salvucci O, Sierra MDLL, Martina JA, McCormick PJ and Tosato G (2006). EphB2 and EphB4 receptors forward signaling promotes SDF-1-induced endothelial cell chemotaxis and branching remodeling. Blood vol. 108, (9) 2914-2922. 10.1182/blood-2006-05-023341
2005
McCormick PJ, Martina JA and Bonifacino JS (2005). Involvement of clathrin and AP-2 in the trafficking of MHC class II molecules to antigen-processing compartments. Proceedings of The National Academy of Sciences of The United States of America vol. 102, (22) 7910-7915. 10.1073/pnas.0502206102
2004
Woolhead CA, McCormick PJ and Johnson AE (2004). Nascent membrane and secretory proteins differ in FRET-detected folding far inside the ribosome and in their exposure to ribosomal proteins. Cell vol. 116, (5) 725-736. 10.1016/S0092-8674(04)00169-2
2003
McCormick PJ, Miao Y, Shao Y, Lin J and Johnson AE (2003). Cotranslational protein integration into the ER membrane is mediated by the binding of nascent chains to translocon proteins. Molecular Cell vol. 12, (2) 329-341. 10.1016/S1097-2765(03)00304-6
Grants
Directing luteinising hormone receptor activity in vivo: A convergent approach to study GPCR molecular complexes
Howell LA and McCormick PJ
£1,000,000 Biotechnology and Biological Sciences Research Council (01-10-2021 - 31-10-2023)
Howell LA and McCormick PJ
£1,000,000 Biotechnology and Biological Sciences Research Council (01-10-2021 - 31-10-2023)
Dissecting Melanocortin Receptor’s Selectivity - Towards Targeted Drug Design
Mccormick P
£75,000 Weismann Institute - UK Joint Research Program Grant (01-10-2021 - 30-09-2023)
Mccormick P
£75,000 Weismann Institute - UK Joint Research Program Grant (01-10-2021 - 30-09-2023)
Exploring the role of adenosine axis in the tumour microenvironment of pancreatic cancer
Grose RP and Tomas-Bort E
£104,971 Barts Charity (01-09-2019 - 28-02-2023)
Grose RP and Tomas-Bort E
£104,971 Barts Charity (01-09-2019 - 28-02-2023)
Super-Resolution Microscopy of live cells in 3D
Ruban A, Pickersgill RW, Rakyan V, Mullineaux CW, Lee DA, Sharp TV, Alves Godinho SI, Stieglitz B, Hanke GT, Darbari VC, Engl CM, Palacios de Castro MI and Thorpe PH
£369,201 Biotechnology and Biological Sciences Research Council (01-05-2020 - 30-04-2021)
Ruban A, Pickersgill RW, Rakyan V, Mullineaux CW, Lee DA, Sharp TV, Alves Godinho SI, Stieglitz B, Hanke GT, Darbari VC, Engl CM, Palacios de Castro MI and Thorpe PH
£369,201 Biotechnology and Biological Sciences Research Council (01-05-2020 - 30-04-2021)