Dr Joanne Nolan
Centre Scientist, QM+Emulate Organs-on-Chips Centre
Research
Cancer, Metastasis, Organ-on-a-chip, Primary cilia, Extracellular matrix, Emulate platform
Interests
Having joined Queen Mary in 2021 Joanne worked on an interdisciplinary CRUK-EPSRC funded project across both SEMS and Barts Cancer Institute. This work, in partnership with Emulate, focused on developing a new organ-on-a-chip model of breast cancer bone metastasis to study the interactions which occur between breast cancer and bone cells. Joanne manages the Centre's suite of Human Emulation Systems and has specialist training in the use of the Emulate platform. She leads development of new models within the centre and will provide support and training for research teams in the design, preparation and analysis of their studies and development of research proposals.Publications
Publications of specific relevance to Predictive in vitro Models2023
Nolan J, Pearce OMT, Screen HRC, Knight MM and Verbruggen SW (2023). Organ-on-a-Chip and Microfluidic Platforms for Oncology in the UK. Cancers vol. 15, (3) 10.3390/cancers150306352021
Verbruggen SW, Thompson CL, Duffy MP, Lunetto S, Nolan J, Pearce OMT, Jacobs CR and Knight MM (2021). Mechanical stimulation modulates osteocyte regulation of cancer cell phenotype. Cancers vol. 13, (12) 10.3390/cancers131229062020
Nolan J, Mahdi AF, Dunne CP and Kiely PA (2020). Collagen and fibronectin promote an aggressive cancer phenotype in breast cancer cells but drive autonomous gene expression patterns. Elsevier Bv Gene vol. 761, 145024-145024. 10.1016/j.gene.2020.145024Mahdi AF, Malacrida B, Nolan J, McCumiskey ME, Merrigan AB, Lal A, Tormey S, Lowery AJ, McGourty K and Kiely PA (2020). Expression of Annexin A2 Promotes Cancer Progression in Estrogen Receptor Negative Breast Cancers. Cells vol. 9, (7) 10.3390/cells9071582Nolan J, Dunne SS, Mustafa W, Sivananthan L, Kiely PA and Dunne CP (2020). Proposed hypothesis and rationale for association between mastitis and breast cancer. Elsevier Bv Medical Hypotheses vol. 144, 110057-110057. 10.1016/j.mehy.2020.1100572019
Franzoni M, O’Connor DT, Marcar L, Power D, Moloney MA, Kavanagh EG, Leask RL, Nolan J, Kiely PA and Walsh MT (2019). The Presence of a High Peak Feature Within Low-Average Shear Stimuli Induces Quiescence in Venous Endothelial Cells. Springer Science and Business Media Llc Annals of Biomedical Engineering vol. 48, (2) 582-594. 10.1007/s10439-019-02371-5