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Dr James Heward

James Heward

Barts Cancer Institute

Research

Drug screening, Epigenetics

Publications of specific relevance to Predictive in vitro Models

Publications

2019

Coetzee A (2019). Targeting FGFR signalling to disrupt cellular cross-talk in pancreatic cancer.
Araf S, Wang J, Korfi K, Pangault C, Kotsiou E, Rio-Machin A, Rahim T, Heward J, Clear A, Iqbal S, Davies JK, Johnson P, Calaminici M, Montoto S, Auer R, Chelala C, Gribben JG, Graham TA, Fest T, Fitzgibbon J and Okosun J (2019). Correction: Genomic profiling reveals spatial intra-tumor heterogeneity in follicular lymphoma (Leukemia, (2018), 32, 5, (1261-1265), 10.1038/s41375-018-0043-y). Leukemia  vol. 33, (6) 10.1038/s41375-019-0425-9

2018

Al Seraihi AF, Rio-Machin A, Tawana K, Bödör C, Wang J, Nagano A, Heward JA, Iqbal S, Best S, Lea N, McLornan D, Kozyra EJ, Wlodarski MW, Niemeyer CM, Scott H, Hahn C, Ellison A, Tummala H, Cardoso SR, Vulliamy T, Dokal I, Butler T, Smith M, Cavenagh J and Fitzgibbon J (2018). GATA2 monoallelic expression underlies reduced penetrance in inherited GATA2-mutated MDS/AML. Springer Nature  Leukemia  vol. 32, (11) 2502-2507. 10.1038/s41375-018-0134-9
Heward JA, Kumar EA, Korfi K, Okosun J and Fitzgibbon J (2018). Precision medicine and lymphoma. Curr Opin Hematol  vol. 25, (4) 329-334. 10.1097/MOH.0000000000000437
Araf S, Wang J, Korfi K, Pangault C, Kotsiou E, Rio-Machin A, Rahim T, Heward J, Clear A, Iqbal S, Davies JK, Johnson P, Calaminici M, Montoto S, Auer R, Chelala C, Gribben JG, Graham TA, Fest T, Fitzgibbon J and Okosun J (2018). Genomic profiling reveals spatial intra-tumor heterogeneity in follicular lymphoma. Leukemia  vol. 32, (5) 1258-1263. 10.1038/s41375-018-0043-y

2017

Hamann PD, Roux BT, Heward JA, Love S, McHugh NJ, Jones SW and Lindsay MA (2017). Transcriptional profiling identifies differential expression of long non-coding RNAs in Jo-1 associated and inclusion body myositis. Nature Publishing Group  Scientific Reports  vol. 7, (1) 10.1038/s41598-017-08603-9
Roux BT, Heward JA, Donnelly LE, Jones SW and Lindsay MA (2017). Catalog of Differentially expressed long non-coding RNA following activation of human and mouse innate immune response. Frontiers Media  Frontiers in Immunology  vol. 8, (AUG) 10.3389/fimmu.2017.01038

2016

GROSE RP, Dawkins JBN, Wang J, maniati , heward , koniali , kocher , martin , chelala , balkwill and fitzgibbon (2016). Reduced expression of histone methyltransferases KMT2C and KMT2D correlates with improved outcome in pancreatic ductal adenocarcinoma. American Association For Cancer Research  Cancer Research  10.1158/0008-5472.CAN-16-0481
Pearson MJ, Philp AM, Heward JA, Roux BT, Walsh DA, Davis ET, Lindsay MA and Jones SW (2016). Long Intergenic Noncoding RNAs Mediate the Human Chondrocyte Inflammatory Response and Are Differentially Expressed in Osteoarthritis Cartilage. Arthritis Rheumatol  vol. 68, (4) 845-856. 10.1002/art.39520
Araf S, Okosun J, Koniali L, Fitzgibbon J and Heward J (2016). Epigenetic dysregulation in follicular lymphoma. Epigenomics  vol. 8, (1) 77-84. 10.2217/epi.15.96

2015

Heward JA, Roux BT and Lindsay MA (2015). Divergent signalling pathways regulate lipopolysaccharide-induced eRNA expression in human monocytic THP1 cells. Febs Lett  vol. 589, (3) 396-406. 10.1016/j.febslet.2014.12.026

2014

Heward JA and Lindsay MA (2014). Long non-coding RNAs in the regulation of the immune response. Trends Immunol  vol. 35, (9) 408-419. 10.1016/j.it.2014.07.005
IIott NE, Heward JA, Roux B, Tsitsiou E, Fenwick PS, Lenzi L, Goodhead I, Hertz-Fowler C, Heger A, Hall N, Donnelly LE, Sims D and Lindsay MA (2014). Long non-coding RNAs and enhancer RNAs regulate the lipopolysaccharide-induced inflammatory response in human monocytes. Nat Commun  vol. 5, 10.1038/ncomms4979