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Dr Hannah Heywood

Hannah Heywood

Research Fellow

School of Engineering and Materials Science
Queen Mary University of London

Research

Organ-on-a-chip, Circadian Rhythm, cartilage, endothelial, mechanical stimuli

Interests

The cells of our body contain a circadian clock mechanism that plays a vital role in coordinating physiological processes and the dysfunction of which is linked to disease. Timing ques, known as Zeitgebers, set the time of the circadian clock and maintain cell synchronicity. My research examines novel zeitgebers and how zeitgebers can be applied to sustain robust circadian rhythmicity in vitro. The aim is to better recapitulate physiological processes in organ on a chip systems.

Publications

Publications of specific relevance to Predictive in vitro Models

2020

Thompson CL, Fu S, Heywood HK, Knight MM and Thorpe SD (2020). Mechanical Stimulation: A Crucial Element of Organ-on-Chip Models. Frontiers Media Sa  Frontiers in Bioengineering and Biotechnology  vol. 8, 10.3389/fbioe.2020.602646

2016

Heywood HK and Lee DA (2016). Bioenergetic reprogramming of articular chondrocytes by exposure to exogenous and endogenous reactive oxygen species and its role in the anabolic response to low oxygen. Journal of Tissue Engineering and Regenerative Medicine  vol. 11, (8) 2286-2294. 10.1002/term.2126

2014

(2014). Culture expansion in low-glucose conditions preserves chondrocyte differentiation and enhances their subsequent capacity to form cartilage tissue in three-dimensional culture. Biores Open Access  vol. 3, (1) 9-18. 10.1089/biores.2013.0051

2013

Pattappa G, Thorpe SD, Jegard NC, Heywood HK, de Bruijn JD and Lee DA (2013). Continuous and Uninterrupted Oxygen Tension Influences the Colony Formation and Oxidative Metabolism of Human Mesenchymal Stem Cells. Tissue Engineering Part C-Methods  vol. 19, (1) 10.1089/ten.tec.2011.0734
Gammon L, Biddle A, Heywood HK, Johannessen AC and Mackenzie IC (2013). Sub-sets of cancer stem cells differ intrinsically in their patterns of oxygen metabolism. Plos One  vol. 8, (4) 10.1371/journal.pone.0062493

2011

Pattappa G, Heywood HK, de Bruijn JD and Lee DA (2011). The metabolism of human mesenchymal stem cells during proliferation and differentiation. J Cell Physiol  vol. 226, (10) 2562-2570. 10.1002/jcp.22605

2010

Pattappa G, Heywood HK, de Bruijn JD and Lee DA (2010). The metabolism of human mesenchymal stem cells during proliferation and differentiation. J Cell Physiol  10.1002/jcp.22605
Martyn SV, Heywood HK, Rockett P, Paine MD, Wang MJ, Dobson PJ, Sheard SJ, Lee DA and Stark JPW (2010). Electrospray deposited fibronectin retains the ability to promote cell adhesion. Journal of Biomedical Materials Research Part B Applied Biomaterials  vol. 96B, (1) 110-118. 10.1002/jbm.b.31745
Heywood HK, Knight MM and Lee DA (2010). Both superficial and deep zone articular chondrocyte subpopulations exhibit the crabtree effect but have different basal oxygen consumption rates. Journal of Cellular Physiology  vol. 223, (3) 630-639. 10.1002/jcp.22061
Heywood HK and Lee DA (2010). Low oxygen reduces the modulation to an oxidative phenotype in monolayer-expanded chondrocytes. J Cell Physiol  vol. 222, (1) 248-253. 10.1002/jcp.21946

2008

Heywood HK and Lee DA (2008). Monolayer expansion induces an oxidative metabolism and ROS in chondrocytes. Biochem Biophys Res Commun  vol. 373, (2) 224-229. 10.1016/j.bbrc.2008.06.011
Heywood HK and Lee DA (2008). The effect of oxygen supply on chondrocyte metabolic phenotype during monolayer culture. European Cells and Materials  vol. 16, (SUPPL. 3)

2006

Heywood HK, Bader DL and Lee DA (2006). Rate of oxygen consumption by isolated articular chondrocytes is sensitive to medium glucose concentration. Journal of Cellular Physiology  vol. 206, (2) 402-410. 10.1002/jcp.20491

2005

Wang MJ, Heywood HK, Bader DL, Paine MD, Stark JPW and Lee DA (2005). Identification and characterization of deposited fibronectin on biocompatible materials: Comparison of electrospray and wetting methods. Proceedings of The 2005 Summer Bioengineering Conference  vol. 2005, 439-440.
Sengers BG, Heywood HK, Lee DA, Oomens CWJ and Bader DL (2005). Nutrient utilization by bovine articular chondrocytes: a combined experimental and theoretical approach. J Biomech Eng  vol. 127, (5) 758-766. 10.1115/1.1993664
Heywood HK, Bader DL and Lee DA (2005). Superficial and deep chondrocyte subpopulations both express the crabtree effect but exhibit differences in oxygen consumption rate. European Cells and Materials  vol. 10, (SUPPL.2)

2004

Heywood HK, Sembi PK, Lee DA and Bader DL (2004). Cellular utilization determines viability and matrix distribution profiles in chondrocyte-seeded alginate constructs. Tissue Eng  vol. 10, (9-10) 1467-1479. 10.1089/ten.2004.10.1467

2003

LEE DA, Heywood HK, Baaijens FPT, Oomens CWJ and Sengers BG (2003). Experimental and theoretical analysis of glucose dependent oxygen utilization by bovine articular chondrocytes. Internat. J. Artificial Organs  vol. 26, 875-875.

Grants

Grants of specific relevance to Predictive in vitro Models
Augmenting sirtuin activity to drive cartilage regeneration and treat osteoarthritis
Lee D and Heywood HK
£150,201 Dunhill Medical Trust (01-11-2014 - 31-12-2016)
Summary