Centre for Predictive in vitro Models
Queen Mary University of London

Torres-Pérez JV, Naeem H, Thompson CL, Knight MM and Novak P (2020). Nanoscale mapping reveals functional differences in ion channels populating the membrane of primary cilia. Cellular Physiology and Biochemistry  vol. 54, (1) 15-26. 10.33594/000000202

Fu S, Thompson CL, Ali A, Wang W, Chapple JP, Mitchison HM, Beales PL, Wann AKT and Knight MM (2019). Mechanical loading inhibits cartilage inflammatory signalling via an HDAC6 and IFT-dependent mechanism regulating primary cilia elongation. Osteoarthritis and Cartilage  vol. 27, (7) 1064-1074. 10.1016/j.joca.2019.03.003

Harris C, THORPE SD, Rushwan S, Wang W, THOMPSON C, Peacock J, KNIGHT M, Gooptu B and Greenough A (2019). An in vitro investigation of the inflammatory response to the strain amplitudes which occur during high frequency oscillation ventilation and conventional mechanical ventilation. Elsevier  Journal of Biomechanics  10.1016/j.jbiomech.2019.03.024

OToole SM, Watson DS, Novoselova TV, Romano LEL, King PJ, Bradshaw TY, Thompson CL, Knight MM, Sharp TV, Barnes MR, Srirangalingam U, Drake WM and Chapple JP (2019). Oncometabolite induced primary cilia loss in pheochromocytoma. Endocrine-Related Cancer  vol. 26, (1) 165-180. 10.1530/ERC-18-0134

Gambassi S, Geminiani M, Thorpe SD, Bernardini G, Millucci L, Braconi D, Orlandini M, Thompson CL, Petricci E, Manetti F, Taddei M, Knight MM and Santucci A (2017). Smoothened-antagonists reverse homogentisic acid-induced alterations of Hedgehog signaling and primary cilium length in alkaptonuria. Journal of Cellular Physiology  vol. 232, (11) 3103-3111. 10.1002/jcp.25761

Thompson CL, Plant JC, Wann AK, Bishop CL, Novak P, Mitchison HM, Beales PL, Chapple JP and Knight MM (2017). Chondrocyte expansion is associated with loss of primary cilia and disrupted hedgehog signalling. Eur Cell Mater  vol. 34, 128-141. 10.22203/eCM.v034a09

Schwarz N, Lane A, Jovanovic K, Parfitt DA, Aguila M, Thompson CL, da Cruz L, Coffey PJ, Chapple JP, Hardcastle AJ and Cheetham ME (2017). Arl3 and RP2 regulate the trafficking of ciliary tip kinesins. (CORRIGENDUM). Oxford University Press  Hum Mol Genet  vol. 26, (17) 3451-3451. 10.1093/hmg/ddx245

Schwarz N, Lane A, Jovanovic K, Parfitt DA, Aguila M, Thompson CL, da Cruz L, Coffey PJ, Chapple JP, Hardcastle AJ and Cheetham ME (2017). Arl3 and RP2 regulate the trafficking of ciliary tip kinesins. Oxford University Press  Hum Mol Genet  vol. 26, (13) 2480-2492. 10.1093/hmg/ddx143

THORPE SD, Gambassi S, Thompson CL, Chandrakumar C, Santucci A and Knight MM (2017). Reduced Primary Cilia Length and Altered Arl13b Expression Are Associated with Deregulated Chondrocyte Hedgehog Signalling in Alkaptonuria. John Wiley & Sons Inc.  Journal of Cellular Physiology  10.1002/jcp.25839

KNIGHT MM, wang W, wang Z, wann A, thompson C and hassen A (2016). IFT88 influences chondrocyte actin organization and biomechanics. Osteoarthritis and Cartilage  10.1016/j.joca.2015.10.003

KNIGHT MM, Thompson CL, Wiles A and Poole CA (2016). Lithium chloride modulates chondrocyte primary cilia and inhibits hedgehog signalling. Federation of American Society of Experimental Biology (Faseb)  The Faseb Journal  10.1096/fj.15-274944

Sliogeryte K, Thorpe SD, Wang Z, Thompson CL, Gavara N and Knight MM (2016). Differential effects of LifeAct-GFP and actin-GFP on cell mechanics assessed using micropipette aspiration. Elsevier  Journal of Biomechanics  vol. 49, (2) 310-317. 10.1016/j.jbiomech.2015.12.034

Thompson CL, Patel R, Kelly T-AN, Wann AKT, Hung CT, Chapple JP and Knight MM (2015). Hedgehog signalling does not stimulate cartilage catabolism and is inhibited by Interleukin-1β. Arthritis Research & Therapy  vol. 17, (1) 10.1186/s13075-015-0891-z

Thompson CL, Poole CA and Knight MM (2015). Lithium chloride modulates chondrocyte primary cilia and inhibits Hedgehog signaling. Federation of American Society of Experimental Biology  The Faseb Journal  vol. 100, (4) A39-A40. 10.1096/fj.15-274944

KNIGHT MM, Thompson CL, Yasmin H, Varone A, Wiles A and Poole CA (2015). Lithium chloride prevents interleukin- 1β induced cartilage degradation and loss of mechanical properties. Wiley: 12 Months  Journal of Orthopaedic Research  10.1002/jor.22913

Thompson CL, Poole CA and Knight MM (2015). Lithium chloride triggers primary cilia elongation and inhibits hedgehog signalling in articular chondrocytes. International Journal of Experimental Pathology  vol. 96, (2) A6-A6.

Thompson CL, Chapple JP and Knight MM (2014). Primary cilia disassembly down-regulates mechanosensitive hedgehog signalling: a feedback mechanism controlling ADAMTS-5 expression in chondrocytes. Osteoarthritis Cartilage  vol. 22, (3) 490-498. 10.1016/j.joca.2013.12.016

McMurray RJ, Wann AKT, Thompson CL, Connelly JT and Knight MM (2013). Surface topography regulates wnt signaling through control of primary cilia structure in mesenchymal stem cells. Sci Rep  vol. 3, 10.1038/srep03545

Wann AK, Thompson CL, Chapple JP and Knight MM (2013). Interleukin-1β sequesters hypoxia inducible factor 2α to the primary cilium. Cilia  vol. 2, (1) 10.1186/2046-2530-2-17

Prodromou NV, Thompson CL, Osborn DPS, Cogger KF, Ashworth R, Knight MM, Beales PL and Chapple JP (2012). Heat shock induces rapid resorption of primary cilia. J Cell Sci  vol. 125, (Pt 18) 4297-4305. 10.1242/jcs.100545

Wann AKT, Thompson C and Knight MM (2012). The role of the primary cilium in chondrocyte response to mechanical loading. Mechanically Gated Channels and Their Regulation  10.1007/978-94-007-5073-9_15