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Dr Clare Thompson

Clare Thompson

Emulate Centre Scientist

Centre for Predictive in vitro Models
Queen Mary University of London
+44 (0)20 7882 3603

Publications of specific relevance to Predictive in vitro Models

Publications

2020

Torres-Pérez JV, Naeem H, Thompson CL, Knight MM and Novak P (2020). Nanoscale mapping reveals functional differences in ion channels populating the membrane of primary cilia. Cellular Physiology and Biochemistry  vol. 54, (1) 15-26. 10.33594/000000202

2019

Fu S, Thompson CL, Ali A, Wang W, Chapple JP, Mitchison HM, Beales PL, Wann AKT and Knight MM (2019). Mechanical loading inhibits cartilage inflammatory signalling via an HDAC6 and IFT-dependent mechanism regulating primary cilia elongation. Osteoarthritis and Cartilage  vol. 27, (7) 1064-1074. 10.1016/j.joca.2019.03.003
Harris C, THORPE SD, Rushwan S, Wang W, THOMPSON C, Peacock J, KNIGHT M, Gooptu B and Greenough A (2019). An in vitro investigation of the inflammatory response to the strain amplitudes which occur during high frequency oscillation ventilation and conventional mechanical ventilation. Elsevier  Journal of Biomechanics  10.1016/j.jbiomech.2019.03.024
OToole SM, Watson DS, Novoselova TV, Romano LEL, King PJ, Bradshaw TY, Thompson CL, Knight MM, Sharp TV, Barnes MR, Srirangalingam U, Drake WM and Chapple JP (2019). Oncometabolite induced primary cilia loss in pheochromocytoma. Endocrine-Related Cancer  vol. 26, (1) 165-180. 10.1530/ERC-18-0134

2017

Gambassi S, Geminiani M, Thorpe SD, Bernardini G, Millucci L, Braconi D, Orlandini M, Thompson CL, Petricci E, Manetti F, Taddei M, Knight MM and Santucci A (2017). Smoothened-antagonists reverse homogentisic acid-induced alterations of Hedgehog signaling and primary cilium length in alkaptonuria. Journal of Cellular Physiology  vol. 232, (11) 3103-3111. 10.1002/jcp.25761
Thompson CL, Plant JC, Wann AK, Bishop CL, Novak P, Mitchison HM, Beales PL, Chapple JP and Knight MM (2017). Chondrocyte expansion is associated with loss of primary cilia and disrupted hedgehog signalling. Eur Cell Mater  vol. 34, 128-141. 10.22203/eCM.v034a09
Schwarz N, Lane A, Jovanovic K, Parfitt DA, Aguila M, Thompson CL, da Cruz L, Coffey PJ, Chapple JP, Hardcastle AJ and Cheetham ME (2017). Arl3 and RP2 regulate the trafficking of ciliary tip kinesins. (CORRIGENDUM). Oxford University Press  Hum Mol Genet  vol. 26, (17) 3451-3451. 10.1093/hmg/ddx245
Schwarz N, Lane A, Jovanovic K, Parfitt DA, Aguila M, Thompson CL, da Cruz L, Coffey PJ, Chapple JP, Hardcastle AJ and Cheetham ME (2017). Arl3 and RP2 regulate the trafficking of ciliary tip kinesins. Oxford University Press  Hum Mol Genet  vol. 26, (13) 2480-2492. 10.1093/hmg/ddx143
THORPE SD, Gambassi S, Thompson CL, Chandrakumar C, Santucci A and Knight MM (2017). Reduced Primary Cilia Length and Altered Arl13b Expression Are Associated with Deregulated Chondrocyte Hedgehog Signalling in Alkaptonuria. John Wiley & Sons Inc.  Journal of Cellular Physiology  10.1002/jcp.25839

2016

KNIGHT MM, wang W, wang Z, wann A, thompson C and hassen A (2016). IFT88 influences chondrocyte actin organization and biomechanics. Osteoarthritis and Cartilage  10.1016/j.joca.2015.10.003
KNIGHT MM, Thompson CL, Wiles A and Poole CA (2016). Lithium chloride modulates chondrocyte primary cilia and inhibits hedgehog signalling. Federation of American Society of Experimental Biology (Faseb)  The Faseb Journal  10.1096/fj.15-274944
Sliogeryte K, Thorpe SD, Wang Z, Thompson CL, Gavara N and Knight MM (2016). Differential effects of LifeAct-GFP and actin-GFP on cell mechanics assessed using micropipette aspiration. Elsevier  Journal of Biomechanics  vol. 49, (2) 310-317. 10.1016/j.jbiomech.2015.12.034

2015

Thompson CL, Patel R, Kelly T-AN, Wann AKT, Hung CT, Chapple JP and Knight MM (2015). Hedgehog signalling does not stimulate cartilage catabolism and is inhibited by Interleukin-1β. Arthritis Research & Therapy  vol. 17, (1) 10.1186/s13075-015-0891-z
Thompson CL, Poole CA and Knight MM (2015). Lithium chloride modulates chondrocyte primary cilia and inhibits Hedgehog signaling. Federation of American Society of Experimental Biology  The Faseb Journal  vol. 100, (4) A39-A40. 10.1096/fj.15-274944
KNIGHT MM, Thompson CL, Yasmin H, Varone A, Wiles A and Poole CA (2015). Lithium chloride prevents interleukin- 1β induced cartilage degradation and loss of mechanical properties. Wiley: 12 Months  Journal of Orthopaedic Research  10.1002/jor.22913
Thompson CL, Poole CA and Knight MM (2015). Lithium chloride triggers primary cilia elongation and inhibits hedgehog signalling in articular chondrocytes. International Journal of Experimental Pathology  vol. 96, (2) A6-A6.

2014

Thompson CL, Chapple JP and Knight MM (2014). Primary cilia disassembly down-regulates mechanosensitive hedgehog signalling: a feedback mechanism controlling ADAMTS-5 expression in chondrocytes. Osteoarthritis Cartilage  vol. 22, (3) 490-498. 10.1016/j.joca.2013.12.016

2013

McMurray RJ, Wann AKT, Thompson CL, Connelly JT and Knight MM (2013). Surface topography regulates wnt signaling through control of primary cilia structure in mesenchymal stem cells. Sci Rep  vol. 3, 10.1038/srep03545
Wann AK, Thompson CL, Chapple JP and Knight MM (2013). Interleukin-1β sequesters hypoxia inducible factor 2α to the primary cilium. Cilia  vol. 2, (1) 10.1186/2046-2530-2-17

2012

Prodromou NV, Thompson CL, Osborn DPS, Cogger KF, Ashworth R, Knight MM, Beales PL and Chapple JP (2012). Heat shock induces rapid resorption of primary cilia. J Cell Sci  vol. 125, (Pt 18) 4297-4305. 10.1242/jcs.100545
Wann AKT, Thompson C and Knight MM (2012). The role of the primary cilium in chondrocyte response to mechanical loading. Mechanically Gated Channels and Their Regulation  10.1007/978-94-007-5073-9_15