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Queen Mary University of London
Centre for Predictive in vitro Models
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Current funding of Predictive in vitro Model research:
£11,453,064

Research Projects

Staff within the Centre for Predictive in vitro Models (CPM) currently hold a large portfolio of grants directly related to the development and use of predictive in vitro models.

The following are current funded research projects led by members of the CPM:

  • Generation of a new stratification strategy based on a new biomarker assay for IBD therapy
    Barts and the London Charity (£49,704)
    16-09-2019 - 15-09-2020
  • Novel Cross-linking Strategy
    Principal Investigator: Julien Gautrot
    FormFormForm Ltd (£105,971)
    01-10-2017 - 30-09-2020
  • Multi-parametric optical sensing for monitoring haemodynamic shock
    Principal Investigator: Pankaj Vadgama
    EPSRC Engineering and Physical Sciences Research Council (£19,434)
    01-10-2017 - 30-09-2020
  • 2D composites with controlled nano-mechanisms
    Principal Investigator: Julien Gautrot
    Leverhulme Trust (£245,677)
    01-03-2018 - 28-02-2021
  • Flow NanoAnalyzer: a next-generation platform for comprehensive extracellular vesicle analysis
    Principal Investigator: Lucy Norling
    Barts and the London Charity (£49,000)
    16-03-2020 - 15-03-2021
  • Development of mechanically enhanced osteoinductive synthetic bone graft substitutes
    Principal Investigator: Karin Hing
    Apatech Ltd (£87,500)
    01-10-2017 - 31-03-2021
  • Understanding the mechanobiology of senescence and ageing
    Principal Investigator: John Connelly
    DMT Dunhill Medical Trust, The (£126,098)
    15-04-2019 - 14-04-2021
  • DNA Nanotechnology for Single Molecule Monitoring
    Principal Investigator: Matteo Palma
    Air Force office of Scientific Research (USA) (£226,637)
    01-06-2017 - 31-05-2021
  • Translating Vasculature-on-a-Chips with a Nephrotoxicity Model
    Principal Investigator: Julien Gautrot
    NC3Rs National Center for the Replacement, Refinement and Reduction of Animals in Research (£49,665)
    01-07-2019 - 30-06-2021
  • Development of a molecular biomarker test for metastatic cancer stem cells in oral squamous cell car
    Principal Investigator: Adrian Biddle
    Oracle Cancer Trust (£93,000)
    02-07-2018 - 01-07-2021
  • Organ-on-a-chip technologies
    Principal Investigator: Hazel Screen
    Co-investigator: Martin Knight
    MRC Medical Research Council (£479,339)
    01-08-2018 - 31-07-2021
  • Expert technical support for CREATE Lab pump-priming projects
    Principal Investigator: John Connelly
    Barts and the London Charity (£191,679)
    01-10-2018 - 30-09-2021
  • Investigating Tendon mechanics and models of tendon pathology
    Principal Investigator: Hazel Screen
    TRB CHEMEDICA Ltd (£63,200)
    01-10-2017 - 30-09-2021
  • Advanced solid tissue models of T-cell migration and activity
    Principal Investigator: Fran Balkwill
    GSK GlaxoSmithKline UK Ltd (£32,000)
    01-10-2017 - 30-09-2021
  • Advanced solid tissue models of T cell migration and activity
    Principal Investigator: Fran Balkwill
    BBSRC Biotechnology and Biological Sciences Research Council (£100,028)
    02-10-2017 - 01-10-2021
  • An in silico structure-based approach to map the druggable allosteric space of membrane receptors
    Principal Investigator: Peter McCormick
    BBSRC Biotechnology and Biological Sciences Research Council (£224,374)
    04-11-2019 - 03-11-2021
  • Engineering the fetal membranes- linked to 404873
    Principal Investigator: Tina Chowdhury
    Prenatal Charity UCL EGA INSTITUTE FOR WOMEN’S HEALTH (£20,000)
    01-12-2018 - 30-11-2021
  • Systems Analysis of Key Nodes in Neurodegenerative Diseases
    Principal Investigator: Peter McCormick
    MRC Medical Research Council (£334,170)
    03-04-2018 - 31-12-2021
  • Multi-sensor array for the acoustic localisation of coronary artery disease
    Principal Investigator: Steve Greenwald
    Queen Mary POC Fund (£49,538)
    01-01-2020 - 01-01-2022
  • Investigating the cardiomyocyte rigidity sensing mechanism with micro patterned surfaces and nanopil
    Principal Investigator: Thomas Iskratsch
    BBSRC Biotechnology and Biological Sciences Research Council (£490,545)
    01-02-2019 - 31-01-2022
  • Combined LAPS and SICM for multimodal live cell imaging
    Principal Investigator: Steffi Krause
    EPSRC Engineering and Physical Sciences Research Council (£504,482)
    01-06-2018 - 31-08-2022
  • A 3Rs approach to tumour metastasis: investigating the role of cancer stem cells in metastasis using an in vitro microfluidic model
    Principal Investigator: Adrian Biddle
    Co-investigator: Julien Gautrot
    NC3Rs National Center for the Replacement, Refinement and Reduction of Animals in Research (£90,000)
    01-10-2019 - 30-09-2022
  • MICA: Organ-on-a-chip models for safety testing of regenerative medicine products
    Principal Investigator: Hazel Screen
    Co-investigator: Martin Knight
    MRC Medical Research Council (£473,325)
    02-12-2019 - 01-12-2022
  • Controlling the haemostatic response: Novel regulatory mechanisms for Von Willebrand factor secretion from endothelial cells
    Principal Investigator: Tom Nightingale
    BHF British Heart Foundation (£232,656)
    01-01-2020 - 31-12-2022
  • Interplay between ovarian cancer stem cells and the tumour microenvironment
    Principal Investigator: Fran Balkwill
    Ovarian Cancer Research Alliance (USA) (£230,324)
    01-01-2020 - 31-12-2022
  • Fungal suppression by human gut Vdelta2 T-cells in mucosal immunity and inflammation
    Principal Investigator: Neil McCarthy
    MRC Medical Research Council (£547,618)
    02-01-2018 - 01-01-2023
  • Exploring the role of adenosine axis in the tumour microenvironment of pancreatic cancer
    Principal Investigator: Daniela Loessner
    Barts and the London Charity (£107,971)
    01-09-2019 - 28-02-2023
  • Reducing pancreatic cancer metastasis by targetting the endothelial cell niche
    Principal Investigator: Kairbaan Hodivala-Dilke
    PCRF Pancreatic Cancer Research Fund (£200,000)
    01-04-2020 - 31-03-2023
  • Organ-on-a-chip model of breast cancer bone metastases
    Principal Investigator: Martin Knight
    CR-UK Cancer Research UK (£268,711)
    01-12-2020 - 31-05-2023
  • Engineered Protein Nanosheets at Liquid-Liquid Interfaces for Stem Cell Expansion, Sorting and Tissue Engineering (PROLICELL)
    Principal Investigator: Julien Gautrot
    EU Commission - Horizon 2020 (£1,499,542)
    01-09-2018 - 31-08-2023
  • New approaches to limit angiogenic responses by controlling endothelial junctional remodelling
    Principal Investigator: Tom Nightingale
    Barts and the London Charity (£233,773)
    01-09-2020 - 31-08-2023
  • The regulation of mechanosensing in healthy and atherosclerotic VSMC
    Principal Investigator: Thomas Iskratsch
    BHF British Heart Foundation (£238,021)
    01-09-2020 - 31-08-2023
  • Organ-on-a-chip Centre of Excellence
    Principal Investigator: Martin Knight
    Co-investigator: Hazel Screen
    Emulate Inc. (£525,375)
    20-08-2019 - 19-09-2023
  • Targeting the innate immune system in high grade serous ovarian cancer
    Principal Investigator: Fran Balkwill
    CR-UK Cancer Research UK (£1,924,190)
    01-10-2018 - 30-09-2023
  • Understanding the mechanisms of epidermal barrier damage and repair using 3D skin equivalent models
    Principal Investigator: John Connelly
    GSK GlaxoSmithKline UK Ltd (£34,000)
    01-10-2019 - 30-09-2023
  • Using a pathway dynamics approach to identify novel EP4 receptor agonists for the treatment of cardiac inflammation and fibrosis (iCASE matching)
    Principal Investigator: Peter McCormick
    Co-investigator: Tom Nightingale
    Barts and the London Charity (£107,727)
    01-10-2019 - 30-09-2023
  • A Biophysical Model of Gum Reintegration on enamel
    Principal Investigator: Julien Gautrot
    GSK GlaxoSmithKline UK Ltd (£32,000)
    01-10-2019 - 30-09-2023
  • 3D bio-printing human pluripotent stem cell-derived skeletal muscle constructs for disease modelling
    Principal Investigator: Yung-Yao Lin
    Co-investigator: John Connelly
    NC3Rs National Center for the Replacement, Refinement and Reduction of Animals in Research (£90,000)
    01-10-2020 - 30-09-2023
  • Roles of Endothelial and Smooth Muscle KATP channels in Myocardial Ischemic Injury
    NIH National Institutes of Health - USA (£325,938)
    01-12-2019 - 30-11-2023
  • Bioactive bioresorbable composites for load bearing guided bone regeneration
    Principal Investigator: Karin Hing
    Baxter Healthcare Corporation (£29,000)
    01-10-2020 - 31-03-2024
  • Reprogramming resolution in the arthritic joint
    Principal Investigator: Lucy Norling
    AR-UK Versus Arthritis (£720,853)
    01-09-2019 - 31-08-2024