QM+Emulate Centre Research Projects
The Queen Mary+Emulate Organs-on-Chips Centre hosts an expanding range of research and development projects and has helped win over £3M of research funding since opening in 2019. The Centre is open for use by external academic institutions and industry and can help support research projects by providing access to Emulate facilities, support from our Centre Scientists and routes to commercialisation.
On this page:
Current Projects
 Development of an arterial organ-chip to study the role of primary cilia in atherosclerosis
|  Development of an organ-chip to study regulation of primary cilia mechanobiology as novel treatment of Polycystic Kidney Disease
|  Human synovium-cartilage organ-chip for personalised surgical screening
|  Organ-on-a-chip model to investigate breast cancer bone metastases
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Completed Projects
 Novel Models of Tendinopathy on a Chip
|  Mechanical regulation of synoviocyte response to pro-inflammatory cytokines and development of a synovium-cartilage chip
|  Organ-on-a-chip models for safety testing of regenerative medicine products
|  Tuneable mechanical microenvironments for organ-chip models - a case study in bone
|  Emulate-Bladder: A new dynamic in vitro human bladder model
|  Generation and validation of a urine-derived, personalised kidney-on-chip model for kidney disease and nephrotoxicity.
|  Understanding the mechanisms of vascular dysfunction in severe COVID-19
|  Modelling anti-fungal immunity in the human intestine
|  Investigating the role of tumour associated myeloid cells on malignant cell invasion in a metastatic high-grade serous ovarian cancer-on-chip model
|  Development of a human placental artery-on-a-chip to study placental vascular function in reproductive toxicology and pregnancy diseases
|  Advancing Human Synovial Joint Chips
|  Interrogating the role of hydrolases on colonic barrier dysfunction
|  Establishing an 'old' and 'young' alveolar model to assess the impact of senescence on immunity to viruses
|  Development of a synovium-chondrocyte organ-on-a-chip model with integrated biomechanical stimulation
|  Feasibility study to assess the use of organ-on-a-chip technology for optimization of radiotherapy cancer treatment.
|  Production and validation of a bovine lung-on-a-chip to study bovine respiratory diseases
|  Precision reprogramming of immune cell metabolism to reduce inflammation and repolarise organ microenvironment using small molecules and metabolic intermediates.
|  Investigating the diagnostic and drug-screening potential of endothelial-to-mesenchymal transition during liver fibrosis.
|  Development of an organ-on-a-chip model for bone
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