Queen Mary University of LondonQueen Mary University of London
Projects menu
Current funding of Predictive in vitro Model research:
£10,083,449

Research Projects

Staff within the Centre for Predictive in vitro Models (CPM) currently hold a portfolio of £18.5M of live grants of which approximately £11M are directly related to the development and use of predictive in vitro models.

The following are examples of current funded research projects led by members of the CPM:

KTP Project - Novel Crosslinking ChemistriesPrincipal Investigator: Julien Gautrot
Innovate UK (£225,205)
15-06-2017 - 14-06-2020
META-DORM - Mechanobiology of METAstatic and DORMant cancer cells in bone marrow lesionsPrincipal Investigator: Martin Knight
EU Commission - Horizon 2020 (£137,844)
01-01-2018 - 29-06-2020
Supramolecular peptide nanotechnology for antimicrobial therapiesPrincipal Investigator: Helena Azevedo
Wellcome Trust (£99,986)
01-05-2018 - 30-06-2020
A microphysiological human 3D neuromuscular platform for modelling DMD and assessing potential therapeuticsPrincipal Investigator: Yung-Yao Lin
Duchenne Parent Project (£18,720)
01-02-2020 - 31-07-2020
Novel Cross-linking StrategyPrincipal Investigator: Julien Gautrot
FormFormForm Ltd (£105,971)
01-10-2017 - 30-09-2020
Expert technical support for CREATE Lab pump-priming projectsPrincipal Investigator: John Connelly
Barts and the London Charity (£191,679)
01-03-2018 - 28-02-2021
2D composites with controlled nano-mechanismsPrincipal Investigator: Julien Gautrot
Leverhulme Trust (£245,677)
01-03-2018 - 28-02-2021
Development of mechanically enhanced osteoinductive synthetic bone graft substitutesPrincipal Investigator: Karin Hing
Apatech Ltd (£87,500)
01-10-2017 - 31-03-2021
Identifying the causes of age-related tendon injuryPrincipal Investigator: Hazel Screen
DMT Dunhill Medical Trust, The (£190,374)
01-10-2018 - 31-03-2021
Understanding the mechanobiology of senescence and ageingPrincipal Investigator: John Connelly
DMT Dunhill Medical Trust, The (£126,098)
15-04-2019 - 14-04-2021
Translating Vasculature-on-a-Chips with a Nephrotoxicity ModelPrincipal Investigator: Julien Gautrot
NC3Rs National Center for the Replacement, Refinement and Reduction of Animals in Research (£49,665)
01-07-2019 - 30-06-2021
Organ-on-a-chip technologiesPrincipal Investigator: Hazel Screen
Co-investigator: Martin Knight
MRC Medical Research Council (£479,339)
01-08-2018 - 31-07-2021
EPSRC Core Equipment CallPrincipal Investigator: Wen Wang
Co-investigator: Martin Knight
EPSRC Engineering and Physical Sciences Research Council (£125,000)
13-02-2020 - 12-08-2021
Investigating Tendon mechanics and models of tendon pathologyPrincipal Investigator: Hazel Screen
TRB CHEMEDICA Ltd (£63,200)
01-10-2017 - 30-09-2021
Advanced solid tissue models of T-cell migration and activityPrincipal Investigator: Fran Balkwill
GSK GlaxoSmithKline UK Ltd (£32,000)
01-10-2017 - 30-09-2021
Advanced solid tissue models of T cell migration and activityPrincipal Investigator: Fran Balkwill
BBSRC Biotechnology and Biological Sciences Research Council (£100,028)
02-10-2017 - 01-10-2021
LIGHT4SIGHT - Light-activated carriers for the controlled delivery of therapeutic peptides in posterior segment eye diseasesPrincipal Investigator: Helena Azevedo
EU Commission - Horizon 2020 (£179,947)
01-11-2019 - 31-10-2021
Immunotheraphy and clear cell ovarian cancerPrincipal Investigator: Fran Balkwill
MRC Medical Research Council (£290,799)
01-01-2019 - 31-12-2021
Investigating the cardiomyocyte rigidity sensing mechanism with micro patterned surfaces and nanopilPrincipal Investigator: Thomas Iskratsch
BBSRC Biotechnology and Biological Sciences Research Council (£490,545)
01-02-2019 - 31-01-2022
THaCH - The effects of hypercholesterolemia on tendon health (Tendon Health and CHolesterol)Principal Investigator: Hazel Screen
EU European Commission - Other (£73,382)
01-09-2016 - 28-03-2022
Joint Protective Actions of Omega-3 Derived Lipid MediatorsPrincipal Investigator: Lucy Norling
Barts and the London Charity (£231,527)
01-04-2019 - 31-03-2022
Combined LAPS and SICM for multimodal live cell imagingPrincipal Investigator: Steffi Krause
EPSRC Engineering and Physical Sciences Research Council (£504,482)
01-06-2018 - 31-08-2022
A 3Rs approach to tumour metastasis: investigating the role of cancer stem cells in metastasis using an in vitro microfluidic modelPrincipal Investigator: Adrian Biddle
Co-investigator: Julien Gautrot
NC3Rs National Center for the Replacement, Refinement and Reduction of Animals in Research (£90,000)
01-10-2019 - 30-09-2022
Organ-on-a-chip model of breast cancer bone metastasesPrincipal Investigator: Martin Knight
CR-UK Cancer Research UK (£268,711)
01-06-2020 - 30-11-2022
MICA: Organ-on-a-chip models for safety testing of regenerative medicine productsPrincipal Investigator: Hazel Screen
Co-investigator: Martin Knight
MRC Medical Research Council (£482,514)
02-12-2019 - 01-12-2022
Interplay between ovarian cancer stem cells and the tumour microenvironmentPrincipal Investigator: Fran Balkwill
Ovarian Cancer Research Alliance (USA) (£230,324)
01-01-2020 - 31-12-2022
Exploring the role of adenosine axis in the tumour microenvironment of pancreatic cancerPrincipal Investigator: Daniela Loessner
Barts and the London Charity (£107,971)
01-09-2019 - 28-02-2023
Engineered Protein Nanosheets at Liquid-Liquid Interfaces for Stem Cell Expansion, Sorting and Tissue Engineering (PROLICELL)Principal Investigator: Julien Gautrot
EU Commission - Horizon 2020 (£1,499,542)
01-09-2018 - 31-08-2023
Organ-on-a-chip Centre of ExcellencePrincipal Investigator: Martin Knight
Co-investigator: Hazel Screen
Emulate Inc. (£525,375)
20-08-2019 - 19-09-2023
Targeting the innate immune system in high grade serous ovarian cancerPrincipal Investigator: Fran Balkwill
CR-UK Cancer Research UK (£1,924,190)
01-10-2018 - 30-09-2023
Understanding the mechanisms of epidermal barrier damage and repair using 3D skin equivalent modelsPrincipal Investigator: John Connelly
GSK GlaxoSmithKline UK Ltd (£34,000)
01-10-2019 - 30-09-2023
A Biophysical Model of Gum Reintegration on enamelPrincipal Investigator: Julien Gautrot
GSK GlaxoSmithKline UK Ltd (£32,000)
01-10-2019 - 30-09-2023
3D bio-printing human pluripotent stem cell-derived skeletal muscle constructs for disease modellingPrincipal Investigator: Yung-Yao Lin
Co-investigator: John Connelly
NC3Rs National Center for the Replacement, Refinement and Reduction of Animals in Research (£90,000)
01-10-2020 - 30-09-2023
Bioactive bioresorbable composites for load bearing guided bone regenerationPrincipal Investigator: Karin Hing
Baxter Healthcare Corporation (£29,000)
01-10-2020 - 31-03-2024
Reprogramming resolution in the arthritic jointPrincipal Investigator: Lucy Norling
AR-UK Versus Arthritis (£720,853)
01-09-2019 - 31-08-2024